AM79

AM79 (10 μM; 8 h) enhances the fluorescence intensity of EGFP-PGC-1α1 in HEK 293-EGFPmPGC-1α1 cells, indicating stabilization of the PGC-1α1 fusion protein, with an activation rate of 57.1% relative to proteasome inhibition^[1].
AM79 (10 μM; 8 h) significantly induces the expression of thermogenic and mitochondrial target genes (including the upregulated expression of *Ucp1*) in fully differentiated immortalized mouse brown adipocytes, without altering the total expression level of the *PGC-1α* gene^[1].
AM79 (10 μM; 8 h) stabilizes endogenous PGC-1α protein in fully differentiated immortalized mouse brown adipocytes^[1].
AM79 (10 μM; 8 h) increases basal mitochondrial respiration and uncoupled mitochondrial respiration (12% increase in proton leak) in fully differentiated immortalized mouse brown adipocytes, with no effect on maximal respiratory capacity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.