DY-46-2
Based on 2 publication(s) in Google Scholar
DY-46-2 is a high potency and selectivity novel non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor with an IC50 value of 0.39 μM.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 1105110-83-5
- Formula: C19H22N6O5S
- Molecular Weight:446.48
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Epigenetics Compound Library
HY-L005
-
Anti-Cancer Compound Library
HY-L025
-
Reprogramming Compound Library
HY-L039
-
Anti-Blood Cancer Compound Library
HY-L079
-
Transcription Factor-Targeted Library
HY-L090
-
Heterocyclic Compound Library
HY-L138
-
Highly Selective Inhibitors Library
HY-L158
-
Anti-Hematopathy Compound Library
HY-L171
-
Bioactive Compound Library Max
HY-L181
-
Epigenetics Compound Library Mini
HY-L005M
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Methylation Compound Library
HY-L203
-
High-Throughput Bioactive Compound Library
HY-L205
-
Anti-Rheumatic Arthritis Compound Library
HY-L210
-
Posttranslational Modification Library
HY-L226
Publications Citing Use of MedChemExpress (MCE) DY-46-2
MoreAll DNA Methyltransferase Isoforms
More
Biological Activity
|
DNMT3A 0.39 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
2.1 μM
Compound: DY-46-2
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 36029561] |
| DU-145 | IC50 |
1.7 μM
Compound: DY-46-2
|
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 36029561] |
| HCT-116 | IC50 |
0.3 μM
Compound: DY-46-2
|
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 36029561] |
| K562 | IC50 |
0.5 μM
Compound: DY-46-2
|
Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 36029561] |
| PBMC | IC50 |
91 μM
Compound: DY-46-2
|
Cytotoxicity activity against human PBMC cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Cytotoxicity activity against human PBMC cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 36029561] |
| THP-1 | IC50 |
0.7 μM
Compound: DY-46-2
|
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human THP-1 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 36029561] |
| U-937 | IC50 |
0.7 μM
Compound: DY-46-2
|
Antiproliferative activity against human U-937 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human U-937 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
|
[PMID: 36029561] |
DY-46-2 (0.1-100 μM, 24, 48 and 72 h) has an inhibitory activity of DNMT3A with an IC50 value of 0.39 μM, which increases linearly with DNA concentration (IDT-01)[1].
DY-46-2 (0.1-100 μM, 24, 48 and 72 h) has inhibitory activity against DNMT1, DNMT3B and G9a with IC50 values of 13.0 μM, 105 μM and ＞500 μM, respectively[1].
DY-46-2 (0.1-100 μM, 24, 48 and 72 h) has cell viability in cancer cells with IC50 values of 0.7 μM, 0.3 μM, 0.7 μM, 0.5 μM, 2.1 μM, 1.7 μM and 91 μM for THP-1, HCT116, U937, K562, A549, DU145 and PBMC cell, respectively[1].
DY-46-2 (0.1-100 μM, 24, 48 and 72 h) markedly inhibits the proliferation of cancer cells and shows low cytotoxicity in peripheral blood mononuclear cells (PBMCs)[1].
DY-46-2 (1 μM, 72 h) obviously decreases DNMT3A protein levels, as well as reactive expression of a silenced TSG (p53) in HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:THP-1, HCT116, U937, K562, A549, DU145 and PBMC cell
-
Concentration:0.1-100 μM
-
Incubation Time:24, 48 and 72 h
-
Result:Had remarkable inhibitory potency in the dose- and time-dependent manners and no cytotoxicity in non-tumoral PBMCs (IC50 >100 μM).
-
Cell Line:THP-1, HCT116, U937, K562, A549, DU145 and PBMC cell
-
Concentration:0.1-100 μM
-
Incubation Time:24, 48 and 72 h
-
Result:Exhibited high anti-proliferative activity with a micromolar range cytotoxicity in all cancer cells.
-
Cell Line:HCT116 cells
-
Concentration:1 μM
-
Incubation Time:72 h
-
Result:Decreased DNMT3A and p53 protein levels in the HCT116 cells, apparently sufficient to reactive expression of a silenced TSG (p53).
Chemical Information
-
CAS No. 1105110-83-5
-
Appearance Solid
-
Molecular Weight 446.48
-
Formula C19H22N6O5S
-
Color White to off-white
-
SMILES
O=C(C1=C(C)OC(N=CN2CCN3CCCC3)=C1C2=O)NC4=CC=C(S(=O)(N)=O)N=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Cell Rep Med
2026 Mar 17;7(3):102687. PMID: 41850232 -
Solvent & Solubility
DMSO : 50 mg/mL (111.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (278 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2397 mL | 11.1987 mL | 22.3974 mL | 55.9935 mL |
| 5 mM | 0.4479 mL | 2.2397 mL | 4.4795 mL | 11.1987 mL | |
| 10 mM | 0.2240 mL | 1.1199 mL | 2.2397 mL | 5.5994 mL | |
| 15 mM | 0.1493 mL | 0.7466 mL | 1.4932 mL | 3.7329 mL | |
| 20 mM | 0.1120 mL | 0.5599 mL | 1.1199 mL | 2.7997 mL | |
| 25 mM | 0.0896 mL | 0.4479 mL | 0.8959 mL | 2.2397 mL | |
| 30 mM | 0.0747 mL | 0.3733 mL | 0.7466 mL | 1.8665 mL | |
| 40 mM | 0.0560 mL | 0.2800 mL | 0.5599 mL | 1.3998 mL | |
| 50 mM | 0.0448 mL | 0.2240 mL | 0.4479 mL | 1.1199 mL | |
| 60 mM | 0.0373 mL | 0.1866 mL | 0.3733 mL | 0.9332 mL | |
| 80 mM | 0.0280 mL | 0.1400 mL | 0.2800 mL | 0.6999 mL | |
| 100 mM | 0.0224 mL | 0.1120 mL | 0.2240 mL | 0.5599 mL |
Powered by Bioz