Cat. No.: HY-N6952

Geraniol

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Geraniol is an olefin terpene with oral activity. Geraniol inhibits cell proliferation and promotes apoptosis. Geraniol has antibacterial, antifungal, antioxidant, anti-inflammatory and antitumor activities. Geraniol can be used to study diabetes.

For research use only. We do not sell to patients.

Purity: 99.79%
CAS No.: 106-24-1
Formula: C₁₀H₁₈O
Molecular Weight:154.25

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Geraniol Chemical Structure

CAS No.: 106-24-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>100 μM Compound: Geraniol	Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry	[PMID: 25455494]
HEK293	IC₅₀	>100 μM Compound: Geraniol	Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry	[PMID: 25455494]
HEK293	IC₅₀	>100 μM Compound: Geraniol	Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ concentration by Fluo-4-AM dye based spectrofluorimetry	[PMID: 25455494]

In Vitro

Geraniol (0.25-1 mM, 24, 48, 72 h) blocks the cell cycle and induces apoptosis in PC-3 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[2]

Cell Line:

PC-3
Concentration:

0.068, 0.125, 0.25, 0.5, 1 mM
Incubation Time:

72 h
Result:

Decreased cell growth in a concentration-dependment manner.

Cell Cycle Analysis ^[2]

Cell Line:

PC-3
Concentration:

0.25, 0.5, 1 mM
Incubation Time:

24 h
Result:

Increased the percentage of G1 and/or sub-G1 phase cells.

Western Blot Analysis ^[2]

Cell Line:

PC-3
Concentration:

0.25, 0.5, 1 mM
Incubation Time:

24 h
Result:

Increased the activity of caspase-3.
Reduced the expressions of four cyclin isotypes (cyclin A, B, D, and E), two of CDK family (CDK1 and CDK4), and two anti-apoptotic Bcl-2 family members (Bcl-2 and Bcl-w).
Elevated the expressions of two CDK inhibitory proteins (p21 and p27) and two pro-apoptotic Bcl-2 family members (Bax and BNIP3).

In Vivo

Geraniol (60, 300 mg/kg, subcutaneously injected into tumor cells daily for 38 consecutive days) inhibits tumor growth in PC-3 nude mouse tumor models^[2].
Geraniol (200 mg/kg, orally, for 45 consecutive days) improves hyperglycemia by reducing a key enzyme in carbohydrate metabolism induced by streptomycin (HY-13753) in diabetic rats^[3].
Geraniol (100 mg/kg/day, orally, for 4 weeks) alleviates oxidative stress, bioaccumulation, serological and histopathological changes during aluminum chloride hepatopancreas poisoning in male Wistar rats^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

PC-3 cell xenograft in nude mice^[2]
Dosage:

60, 300 mg/kg
Administration:

s.c.
Result:

Reduced the tumor volume and weight.
Increased the percentage of apoptotic cells and reduced the expression level of Ki-67.

Animal Model:

Streptozotocin-induced diabetic rats ^[3]
Dosage:

200 mg/kg
Administration:

p.o.
Result:

Decreased the body weight in diabetes rats and decreased blood glucose and increased plasma insulin to near normal.
Reverted the levels of Hb and HbA1C towards near normal and reversed the activities of these enzymes to near normal.

Animal Model:

Aluminum chloride-hepatopancreatic toxicity rats^[4]
Dosage:

100 mg/kg
Administration:

p.o.
Result:

Reduced AST, ALT, ALP, LDH, pancreatic enzymes and FBS levels.
Reduced the MDA and Increased the TAC levels.

Chemical Information

CAS No. 106-24-1
Appearance Liquid (Density: 0.879 g/cm³)
Molecular Weight 154.25
Formula C₁₀H₁₈O
Color Colorless to light yellow
SMILES

C/C(C)=C\CC/C(C)=C/CO
Structure Classification
- Terpenoids
- Other Monoterpenes
Initial Source
- Plants
- other families
- Endogenous metabolite
- Marine natural products
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (2)

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Journal Impact Factor

Pestic Biochem Physiol

Mechanistic insights into chlorogenic acid and caffeic acid as novel juvenile hormone antagonists. [Abstract]

2025 Dec:215:106655. PMID: 41162045
J Neuroimmunol

Geraniol (GER) attenuated chronic sleep restriction (CSR)-induced neuroinflammation in adolescent mice. [Abstract]

2024 Aug 15:393:578400. PMID: 38991453

Solvent & Solubility

In Vitro:

H₂O : 1 mg/mL (6.48 mM; ultrasonic and warming and heat to 80°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.4830 mL

32.4149 mL

64.8298 mL

5 mM

1.2966 mL

6.4830 mL

12.9660 mL

10 mM

---

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (648.30 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bard M, et al. Geraniol interferes with membrane functions in strains of Candida and Saccharomyces. Lipids. 1988 Jun;23(6):534-8. [Content Brief]

[2]. Kim SH, et al. Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways. Biochem Biophys Res Commun. 2011 Apr 1;407(1):129-34. [Content Brief]

[3]. Babukumar S, et al. Geraniol, a natural monoterpene, ameliorates hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Pharm Biol. 2017 Dec;55(1):1442-1449. [Content Brief]

[4]. Hosseini SM, et al. Geraniol attenuates oxidative stress, bioaccumulation, serological and histopathological changes during aluminum chloride-hepatopancreatic toxicity in male Wistar rats. Environ Sci Pollut Res Int. 2020 Jun;27(16):20076-20089. [Content Brief]

[5]. Pereira Fde O, et al. Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, against Trichophyton rubrum involves inhibition of ergosterol biosynthesis. Pharm Biol. 2015 Feb;53(2):228-34. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	6.4830 mL	32.4149 mL	64.8298 mL	162.0746 mL
H₂O	5 mM	1.2966 mL	6.4830 mL	12.9660 mL	32.4149 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Geraniol

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Publications Citing Use of MedChemExpress (MCE) Geraniol

All Endogenous Metabolite Isoforms