oLOX
oLOX is a fluorescent activity reporter. oLOX can be activated by lysyl oxidase family (LOXF) enzymes, which in turn releases a luciferin fluorescent product that reports LOXF enzyme activity. After oLOX is activated in in vitro fibrotic lung tissues, the fluorescence intensity increases, enabling real-time detection of fibrotic activity. oLOX can be used in studies related to pulmonary fibrosis.
For research use only. We do not sell to patients.
- CAS No.: 2241794-11-4
- Formula: C26H26N2O5
- Molecular Weight:446.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
oLOX (10 μM; 2 h) exhibits up to a 300% increase in fluorescence in aged human lung tissue homogenate, with significant signal amplification detected after 30 min and signal plateauing between 50 min and 2 h[1].
oLOX (200 μM) generates a significant increase in fluorescent signal in fibrotic regions of ventilating ex vivo asinine lung detectable via FCFM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2241794-11-4
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Molecular Weight 446.50
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Formula C26H26N2O5
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SMILES
NCCCOC1=CC2=C(C3(C4=C(O2)C=C(C=C4)OCCCN)OC(C5=C3C=CC=C5)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
oLOX Related Classifications
HY-D3208 Related Classifications
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