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Cat. No.: HY-169735

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Aurora A inhibitor 4

Aurora A inhibitor 4 (compound C9) is a potent inhibitor of Aurora A, with the GI₅₀ of 4.26 and 7.08 μM in DU 145 cells and HT-29 cells, respectively.

For research use only. We do not sell to patients.

CAS No.: 371224-09-8
Formula: C₂₂H₂₃N₅O₃
Molecular Weight:405.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Aurora A inhibitor 4 Chemical Structure

CAS No.: 371224-09-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Aurora A inhibitor 4 (compound C9) is a potent inhibitor of Aurora A, with the GI₅₀ of 4.26 and 7.08 μM in DU 145 cells and HT-29 cells, respectively^[1].

IC₅₀ & Target

Aurora A

All Aurora Kinase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	GI₅₀	4.26 μM Compound: BAS 0345 0373	Cytotoxicity against human DU145 cells after 4 hrs by MTT assay Cytotoxicity against human DU145 cells after 4 hrs by MTT assay	[PMID: 21194953]
HT-29	GI₅₀	7.08 μM Compound: BAS 0345 0373	Cytotoxicity against human HT-29 cells after 4 hrs by MTT assay Cytotoxicity against human HT-29 cells after 4 hrs by MTT assay	[PMID: 21194953]

Chemical Information

CAS No. 371224-09-8
Molecular Weight 405.45
Formula C₂₂H₂₃N₅O₃
SMILES

O=C1N=C(NC(C1)C2=CC=C(C=C2)OC)NC3=NC(C)=C4C=C(OCC)C=CC4=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mohammad Neaz Morshed, et al. Computational approach to the identification of novel Aurora-A inhibitors. Bioorg Med Chem. 2011 Jan 15;19(2):907-16. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Aurora A inhibitor 4

All Aurora Kinase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Aurora A inhibitor 4 Related Classifications

HY-169735 Related Classifications