1. Anti-infection
  2. Bacterial
  3. AVX 13616

AVX 13616 

Cat. No.: HY-16672
Handling Instructions

AVX 13616 shows the potent in vivo antibacterial activity of Avexa’s lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens.

For research use only. We do not sell to patients.

AVX 13616 Chemical Structure

AVX 13616 Chemical Structure

CAS No. : 900814-48-4

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Description

AVX 13616 shows the potent in vivo antibacterial activity of Avexa’s lead antibacterial candidate; particularly against drug-resistant Staphylococcus pathogens. IC50 value: 2-4 ug/ml (MICs) Target: antibacterial agent AVX13616 was as active as mupirocin in a nasal decolonization model but required only a single application. The compounds are being developed for topical indications and/or wound infection/catheter-related infections. AVX13616 and other compounds showed broad spectrum antibacterial activity against a range of isolates with MICs of 2-4 micrograms per millilitre against S. aureus, coagulase negative staphylococci, enterococci, MRSA, VISA and VRSA. A single application of 5% (w/w) AVX13616 (approximately equimolar to 2% mupirocin) was as effective as 2% mupirocin administered twice a day for five days in nasal decolonisation of MRSA in mice.

Molecular Weight

955.06

Formula

C50H73Cl2N7O7

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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AVX 13616
Cat. No.:
HY-16672
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