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Cat. No.: HY-133906

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AX13057

AX13057 is a KIAA1363 inhibitor with an IC₅₀ of 130 nM. AX13057 exhibits tumor penetration and is orally active. AX13057 can be used for research on ovarian cancer.

For research use only. We do not sell to patients.

CAS No.: 1397274-79-1
Formula: C₁₆H₁₈BrNO₂
Molecular Weight:336.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AX13057 Chemical Structure

CAS No.: 1397274-79-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

AX13057 is a KIAA1363 inhibitor with an IC₅₀ of 130 nM. AX13057 exhibits tumor penetration and is orally active. AX13057 can be used for research on ovarian cancer^[1].

IC₅₀ & Target

^[1]

KIAA1363

130 nM (IC₅₀)

In Vivo

AX13057 (100 mg/kg; p.o. and i.p.) inhibits intratumoral KIAA1363 in SK-OV-3 xenograft-bearing female SCID mice, producing greater inhibition after i.p. dosing than after p.o. dosing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SCID (female)^[1]
Dosage:

100 mg/kg (p.o.); 100 mg/kg (i.p.)
Administration:

p.o.; i.p.
Result:

Inhibited tumor KIAA1363 by 22% after p.o. dosing with AX13057 at 100 mg/kg.
Inhibited intratumoral human KIAA1363 by 64% and mouse heart KIAA1363 by 66% after i.p. dosing with AX13057 at 100 mg/kg.

Chemical Information

CAS No. 1397274-79-1
Molecular Weight 336.23
Formula C₁₆H₁₈BrNO₂
SMILES

O=C(OC=1C=CC2=CC(=CC=C2C1Br)CCC)N(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shreder KR, et al. Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1). Bioorganic & medicinal chemistry letters. 2012 Sep 01;22(17):5748-51. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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