BC-23
Based on 1 Customer Validation
BC-23 (NSC 45382) is a proteasome inhibitor. BC-23 exhibits good inhibition of CT-L activity of the proteasome and is selective for malignant over normal cells.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 97.37%
- CAS No.: 6298-15-3
- 화학식: C21H14ClN3O4S
- 분자량:439.87
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Ubiquitination Compound Library
HY-L050
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Anti-Blood Cancer Compound Library
HY-L079
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Protease Inhibitor Library
HY-L147
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Highly Selective Inhibitors Library
HY-L158
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
12.19 μM
Compound: PI-083
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Antiproliferative activity against human A549 cells
Antiproliferative activity against human A549 cells
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[PMID: 22437113] |
| DU-145 | IC50 |
10.82 μM
Compound: PI-083
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Antiproliferative activity against human DU145 cells
Antiproliferative activity against human DU145 cells
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[PMID: 22437113] |
| KB | IC50 |
9.57 μM
Compound: PI-083
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Antiproliferative activity against human KB cells
Antiproliferative activity against human KB cells
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[PMID: 22437113] |
| MCF7 | IC50 |
1.96 μM
Compound: PI-083
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Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs MTT assay
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[PMID: 33039723] |
| MCF7 | IC50 |
6 μM
Compound: PI-083, NSC-45382
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Inhibition of 26S proteasome-mediated chymotrypsin like proteolytic activity in human MCF7 cells
Inhibition of 26S proteasome-mediated chymotrypsin like proteolytic activity in human MCF7 cells
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[PMID: 20621484] |
Chemical Information
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CAS No. 6298-15-3
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Appearance Solid
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분자량 439.87
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화학식 C21H14ClN3O4S
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Color Orange to red
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SMILES
O=S(C1=CC=C(C=C1)NC(C2=O)=C(C(C3=C2C=CC=C3)=O)Cl)(NC4=NC=CC=C4)=O
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Synonyms
NSC 45382
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 25 mg/mL (56.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Lawrence HR, et, al. Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92. [Content Brief]
[2]. Zhang Q, et, al. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One. 2016 Mar 25;11(3):e0152407. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2734 mL | 11.3670 mL | 22.7340 mL | 56.8350 mL |
| 5 mM | 0.4547 mL | 2.2734 mL | 4.5468 mL | 11.3670 mL | |
| 10 mM | 0.2273 mL | 1.1367 mL | 2.2734 mL | 5.6835 mL | |
| 15 mM | 0.1516 mL | 0.7578 mL | 1.5156 mL | 3.7890 mL | |
| 20 mM | 0.1137 mL | 0.5683 mL | 1.1367 mL | 2.8417 mL | |
| 25 mM | 0.0909 mL | 0.4547 mL | 0.9094 mL | 2.2734 mL | |
| 30 mM | 0.0758 mL | 0.3789 mL | 0.7578 mL | 1.8945 mL | |
| 40 mM | 0.0568 mL | 0.2842 mL | 0.5683 mL | 1.4209 mL | |
| 50 mM | 0.0455 mL | 0.2273 mL | 0.4547 mL | 1.1367 mL |
BC-23 Related Classifications
HY-119288 Related Classifications
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