2. Metabolic Enzyme/Protease
  3. Proteasome
  4. BC-23

BC-23 (NSC 45382) is a proteasome inhibitor. BC-23 exhibits good inhibition of CT-L activity of the proteasome and is selective for malignant over normal cells.

For research use only. We do not sell to patients.

BC-23 Chemical Structure

BC-23 Chemical Structure

CAS No. : 6298-15-3

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5 mg USD 240 In-stock
10 mg USD 385 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

BC-23 (NSC 45382) is a proteasome inhibitor. BC-23 exhibits good inhibition of CT-L activity of the proteasome and is selective for malignant over normal cells[1][2].

Molecular Weight

439.87

Formula

C21H14ClN3O4S
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

O=S(C1=CC=C(C=C1)NC(C2=O)=C(C(C3=C2C=CC=C3)=O)Cl)(NC4=NC=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (56.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2734 mL 11.3670 mL 22.7340 mL
5 mM 0.4547 mL 2.2734 mL 4.5468 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2734 mL 11.3670 mL 22.7340 mL 56.8350 mL
5 mM 0.4547 mL 2.2734 mL 4.5468 mL 11.3670 mL
10 mM 0.2273 mL 1.1367 mL 2.2734 mL 5.6835 mL
15 mM 0.1516 mL 0.7578 mL 1.5156 mL 3.7890 mL
20 mM 0.1137 mL 0.5683 mL 1.1367 mL 2.8417 mL
25 mM 0.0909 mL 0.4547 mL 0.9094 mL 2.2734 mL
30 mM 0.0758 mL 0.3789 mL 0.7578 mL 1.8945 mL
40 mM 0.0568 mL 0.2842 mL 0.5683 mL 1.4209 mL
50 mM 0.0455 mL 0.2273 mL 0.4547 mL 1.1367 mL
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BC-23 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BC-236298-15-3NSC 45382BC23BC 23NSC45382NSC-45382ProteasomeInhibitorinhibitorinhibit

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