Betulin diacetate
Based on 1 Customer Validation
Betulin diacetate, a triterpene and derivative of Betulin, is an anti-AID agent and also possesses anti-cancer activity.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 1721-69-3
- Formula: C34H54O4
- Molecular Weight:526.79
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Anti-Infection Compound Library
HY-L002
-
Immunology/Inflammation Compound Library
HY-L007
-
Natural Product Library
HY-L021
-
Anti-Cancer Compound Library
HY-L025
-
Antiviral Compound Library
HY-L027
-
Terpenoids Library
HY-L056
-
Anti-Cancer Natural Product Library
HY-L107
-
Plant-Sourced Natural Product Library
HY-L115
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 518A2 | EC50 |
>30 μM
Compound: 1
|
Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
|
[PMID: 27142753] |
| 518A2 | EC50 |
>30 μM
Compound: 29
|
Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
|
[PMID: 26547057] |
| A2780 | EC50 |
>30 μM
Compound: 29
|
Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
|
[PMID: 26547057] |
| A2780 | EC50 |
>30 μM
Compound: 29
|
Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
|
[PMID: 31718946] |
| A2780 | EC50 |
20.3 μM
Compound: 1
|
Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
|
[PMID: 27142753] |
| A2780 | IC50 |
>=20 μg/mL
Compound: 6a
|
Cytotoxicity against human A2780 cells
Cytotoxicity against human A2780 cells
|
[PMID: 12662105] |
| A-375 | EC50 |
>30 μM
Compound: 29
|
Cytotoxicity against human A375 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
Cytotoxicity against human A375 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
|
[PMID: 31718946] |
| A549 | EC50 |
>30 μM
Compound: 29
|
Cytotoxicity against human A549 cells after 96 hrs by SRB assay
Cytotoxicity against human A549 cells after 96 hrs by SRB assay
|
[PMID: 26547057] |
| A549 | EC50 |
21.5 μM
Compound: 1
|
Cytotoxicity against human A549 cells after 96 hrs by SRB assay
Cytotoxicity against human A549 cells after 96 hrs by SRB assay
|
[PMID: 27142753] |
| B16 | ED50 |
3.4 μM
Compound: 8
|
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
|
[PMID: 12027734] |
| B16 | IC50 |
36.8 μM
Compound: 8
|
Growth inhibition of mouse B16 2F2 cells after 3 days
Growth inhibition of mouse B16 2F2 cells after 3 days
|
[PMID: 12027734] |
| BXPC-3 | GI50 |
>10 μg/mL
Compound: 5
|
Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay
Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay
|
[PMID: 24694263] |
| DU-145 | GI50 |
>10 μg/mL
Compound: 5
|
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
Cytotoxicity against human DU145 cells after 48 hrs by SRB assay
|
[PMID: 24694263] |
| FaDu | EC50 |
>30 μM
Compound: 29
|
Cytotoxicity against human FADU cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
Cytotoxicity against human FADU cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
|
[PMID: 31718946] |
| H9 | EC50 |
>189.8 μM
Compound: 24
|
Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound able to suppress HIV replication by 50%.
Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound able to suppress HIV replication by 50%.
|
[PMID: 9804704] |
| H9 | IC50 |
>189.8 μM
Compound: 24
|
Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound toxic to 50% of mock-infected H9 cells.
Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound toxic to 50% of mock-infected H9 cells.
|
[PMID: 9804704] |
| HeLa | EC50 |
>30 μM
Compound: 1
|
Cytotoxicity against human HeLa cells after 96 hrs by SRB assay
Cytotoxicity against human HeLa cells after 96 hrs by SRB assay
|
[PMID: 27142753] |
| HT-29 | EC50 |
>30 μM
Compound: 29
|
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
|
[PMID: 31718946] |
| HT-29 | EC50 |
25.7 μM
Compound: 1
|
Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
|
[PMID: 27142753] |
| KM-20L2 | GI50 |
>10 μg/mL
Compound: 5
|
Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay
Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay
|
[PMID: 24694263] |
| MCF7 | EC50 |
>30 μM
Compound: 1
|
Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
|
[PMID: 27142753] |
| MCF7 | EC50 |
>30 μM
Compound: 29
|
Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
|
[PMID: 26547057] |
| MCF7 | EC50 |
>30 μM
Compound: 29
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
|
[PMID: 31718946] |
| MCF7 | GI50 |
>10 μg/mL
Compound: 5
|
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
|
[PMID: 24694263] |
| NCI-H460 | GI50 |
>10 μg/mL
Compound: 5
|
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay
|
[PMID: 24694263] |
| NIH3T3 | EC50 |
>30 μM
Compound: 29
|
Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
|
[PMID: 26547057] |
| NIH3T3 | EC50 |
>30 μM
Compound: 29
|
Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability incubated for 96 hrs by SRB assay
|
[PMID: 31718946] |
| P388 | ED50 |
0.806 μg/mL
Compound: 5
|
Cytotoxicity against mouse P388 cells after 48 hrs
Cytotoxicity against mouse P388 cells after 48 hrs
|
[PMID: 24694263] |
| SF-268 | GI50 |
>10 μg/mL
Compound: 5
|
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
Cytotoxicity against human SF268 cells after 48 hrs by SRB assay
|
[PMID: 24694263] |
Chemical Information
-
CAS No. 1721-69-3
-
Appearance Solid
-
Molecular Weight 526.79
-
Formula C34H54O4
-
Color White to off-white
-
SMILES
CC(OC[C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)([C@H](CC5)OC(C)=O)C)([H])CC4)C)([H])CC3)C)C)=O
-
Synonyms
Betulin 3,28-diacetate
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
Ethanol : 5 mg/mL (9.49 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
-
Handling Instructions (2659 KB)
References
[1]. I C Sun, et al. Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents. J Med Chem. 1998 Nov 5;41(23):4648-57. [Content Brief]
[2]. T P Shakhtshneider, et al. New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents. Nat Prod Res. 2016 Jun;30(12):1382-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.8983 mL | 9.4914 mL | 18.9829 mL | 47.4572 mL |
| 5 mM | 0.3797 mL | 1.8983 mL | 3.7966 mL | 9.4914 mL |
Betulin diacetate Related Classifications
HY-N9437 Related Classifications
Powered by Bioz