2. PROTAC
  3. PROTAC Linkers
  4. Biotin-PEG3-NHS ester

Biotin-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

For research use only. We do not sell to patients.

Biotin-PEG3-NHS ester Chemical Structure

Biotin-PEG3-NHS ester Chemical Structure

CAS No. : 1253286-56-4

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25 mg USD 45 In-stock
50 mg USD 75 In-stock
100 mg USD 120 In-stock
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Based on 1 publication(s) in Google Scholar

Biotin-PEG3-NHS ester Related Antibodies

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Description

Biotin-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biotin-PEG3-NHS ester Related Antibodies
Molecular Weight

544.62

Formula

C23H36N4O9S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCNC(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (183.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8361 mL 9.1807 mL 18.3614 mL
5 mM 0.3672 mL 1.8361 mL 3.6723 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8361 mL 9.1807 mL 18.3614 mL 45.9036 mL
5 mM 0.3672 mL 1.8361 mL 3.6723 mL 9.1807 mL
10 mM 0.1836 mL 0.9181 mL 1.8361 mL 4.5904 mL
15 mM 0.1224 mL 0.6120 mL 1.2241 mL 3.0602 mL
20 mM 0.0918 mL 0.4590 mL 0.9181 mL 2.2952 mL
25 mM 0.0734 mL 0.3672 mL 0.7345 mL 1.8361 mL
30 mM 0.0612 mL 0.3060 mL 0.6120 mL 1.5301 mL
40 mM 0.0459 mL 0.2295 mL 0.4590 mL 1.1476 mL
50 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9181 mL
60 mM 0.0306 mL 0.1530 mL 0.3060 mL 0.7651 mL
80 mM 0.0230 mL 0.1148 mL 0.2295 mL 0.5738 mL
100 mM 0.0184 mL 0.0918 mL 0.1836 mL 0.4590 mL
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Biotin-PEG3-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG3-NHS ester1253286-56-4PROTAC LinkersProtaclinkerpegcancerInhibitorinhibitorinhibit

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