2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Biotin-PEG4-MeTz

Biotin-PEG4-MeTz is a click chemistry reagent containing a terminal methyltetrazine group that reacts with trans-cyclooctene. Biotin-PEG4-MeTz can be used for the preparation of biotinylated conjugates.

For research use only. We do not sell to patients.

Biotin-PEG4-MeTz Chemical Structure

Biotin-PEG4-MeTz Chemical Structure

CAS No. : 1962919-31-8

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1 mg USD 105 In-stock
5 mg USD 310 In-stock
10 mg USD 500 In-stock
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Based on 1 publication(s) in Google Scholar

Biotin-PEG4-MeTz Related Antibodies

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Description

Biotin-PEG4-MeTz is a click chemistry reagent containing a terminal methyltetrazine group that reacts with trans-cyclooctene. Biotin-PEG4-MeTz can be used for the preparation of biotinylated conjugates[1].

Molecular Weight

674.81

Formula

C31H46N8O7S
CAS No.
Appearance

Solid

Color

Purple to purplish red

SMILES

CC1=NN=C(N=N1)C(C=C2)=CC=C2CNC(CCOCCOCCOCCOCCNC(CCCC[C@H]3[C@]4([H])[C@](NC(N4)=O)([H])CS3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (370.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4819 mL 7.4095 mL 14.8190 mL
5 mM 0.2964 mL 1.4819 mL 2.9638 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4819 mL 7.4095 mL 14.8190 mL 37.0475 mL
5 mM 0.2964 mL 1.4819 mL 2.9638 mL 7.4095 mL
10 mM 0.1482 mL 0.7409 mL 1.4819 mL 3.7047 mL
15 mM 0.0988 mL 0.4940 mL 0.9879 mL 2.4698 mL
20 mM 0.0741 mL 0.3705 mL 0.7409 mL 1.8524 mL
25 mM 0.0593 mL 0.2964 mL 0.5928 mL 1.4819 mL
30 mM 0.0494 mL 0.2470 mL 0.4940 mL 1.2349 mL
40 mM 0.0370 mL 0.1852 mL 0.3705 mL 0.9262 mL
50 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.7409 mL
60 mM 0.0247 mL 0.1235 mL 0.2470 mL 0.6175 mL
80 mM 0.0185 mL 0.0926 mL 0.1852 mL 0.4631 mL
100 mM 0.0148 mL 0.0741 mL 0.1482 mL 0.3705 mL
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Biotin-PEG4-MeTz Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biotin-PEG4-MeTz1962919-31-8ADC LinkerAntibody-drug conjugates linkermethyltetrazinetrans-cyclooctenebiotinylated conjugatesInhibitorinhibitorinhibit

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