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Cat. No.: HY-10335

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BMS-645737

BMS-645737 is an orally active, selective FGF receptor-1 and VEGF receptor-2 inhibitor. BMS-645737 selectively and competitively inhibits both VEGFR-2 and FGFR-1 tyrosine kinases. BMS-645737 has anti-angiogenic activity. BMS-645737 induces lesions in the incisor teeth.

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CAS No.: 651744-16-0
Formule: C₂₀H₂₀N₈O
Masse moléculaire:388.44

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BMS-645737 Chemical Structure

CAS No.: 651744-16-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
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Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

FGFR1

VEGFR2

Voir tous les produits spécifiques à Isoform VEGFR :

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Cellular Effect

Cell Line	Type	Value	Description	References
GTL 16 cell line	IC₅₀	>10 μM Compound: 13, BMS-645737	Antitumor activity against human GTL16 cells Antitumor activity against human GTL16 cells	[PMID: 18395443]
HUVEC	IC₅₀	13 nM Compound: 13, BMS-645737	Antiproliferative activity against VEGF-induced HUVEC Antiproliferative activity against VEGF-induced HUVEC	[PMID: 18395443]
HUVEC	IC₅₀	138 nM Compound: 13, BMS-645737	Antiproliferative activity against bFGF-induced HUVEC Antiproliferative activity against bFGF-induced HUVEC	[PMID: 18395443]
L2987	IC₅₀	>2500 nM Compound: 13, BMS-645737	Antitumor activity against human L2987 cells xenografted in mouse Antitumor activity against human L2987 cells xenografted in mouse	[PMID: 18395443]
NCI-N87	IC₅₀	>10 μM Compound: 13, BMS-645737	Antitumor activity against human N87 cells Antitumor activity against human N87 cells	[PMID: 18395443]

Chemical Information

CAS No. 651744-16-0
Masse moléculaire 388.44
Formule C₂₀H₂₀N₈O
SMILES

N=1N=C(OC1C2=CN3N=CN=C(NC=4C=NC=5NC(=CC5C4)C)C3=C2C(C)C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Fletcher AM, et al. Incisor degeneration in rats induced by vascular endothelial growth factor/fibroblast growth factor receptor tyrosine kinase inhibition. Toxicol Pathol. 2010 Feb;38(2):267-79. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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BMS-645737

Voir tous les produits spécifiques à Isoform VEGFR

Voir tous les produits spécifiques à Isoform FGFR

Activité biologique

Description

IC50 & Target

Cellular Effect

Chemical Information

Pureté et documentation

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BMS-645737 Related Classifications

HY-10335 Related Classifications

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