BMS-645737
BMS-645737 is an orally active, selective FGF receptor-1 and VEGF receptor-2 inhibitor. BMS-645737 selectively and competitively inhibits both VEGFR-2 and FGFR-1 tyrosine kinases. BMS-645737 has anti-angiogenic activity. BMS-645737 induces lesions in the incisor teeth.
For research use only. We do not sell to patients.
- CAS No.: 651744-16-0
- Formula: C20H20N8O
- Molecular Weight:388.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All VEGFR Isoforms
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Biological Activity
|
FGFR1 |
VEGFR2 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| GTL 16 cell line | IC50 |
>10 μM
Compound: 13, BMS-645737
|
Antitumor activity against human GTL16 cells
Antitumor activity against human GTL16 cells
|
[PMID: 18395443] |
| HUVEC | IC50 |
13 nM
Compound: 13, BMS-645737
|
Antiproliferative activity against VEGF-induced HUVEC
Antiproliferative activity against VEGF-induced HUVEC
|
[PMID: 18395443] |
| HUVEC | IC50 |
138 nM
Compound: 13, BMS-645737
|
Antiproliferative activity against bFGF-induced HUVEC
Antiproliferative activity against bFGF-induced HUVEC
|
[PMID: 18395443] |
| L2987 | IC50 |
>2500 nM
Compound: 13, BMS-645737
|
Antitumor activity against human L2987 cells xenografted in mouse
Antitumor activity against human L2987 cells xenografted in mouse
|
[PMID: 18395443] |
| NCI-N87 | IC50 |
>10 μM
Compound: 13, BMS-645737
|
Antitumor activity against human N87 cells
Antitumor activity against human N87 cells
|
[PMID: 18395443] |
Chemical Information
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CAS No. 651744-16-0
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Molecular Weight 388.44
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Formula C20H20N8O
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SMILES
N=1N=C(OC1C2=CN3N=CN=C(NC=4C=NC=5NC(=CC5C4)C)C3=C2C(C)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)