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Cat. No.: HY-115357

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BMS711939

BMS711939 is a selective agonist for peroxisome proliferator-activated receptor α (PPAR α), with EC₅₀ of 4 nM and 4.5 μM, for human PPARα and human PPARγ. BMS711939 exhibits good pharmacokinetic characters in rats models. BMS711939 increases HDL cholesterol, reduces LDL cholesterol and triglycerides.

For research use only. We do not sell to patients.

CAS No.: 1000998-62-8
Formula: C₂₂H₂₀ClFN₂O₆
Molecular Weight:462.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BMS711939 Chemical Structure

CAS No.: 1000998-62-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

hPPARα

4 nM (IC₅₀)

hPPARγ

4.5 μM (IC₅₀)

All PPAR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	4 nM Compound: 3; BMS-711939	Agonist activity at Gal4-tagged human PPAR-alpha expressed in HEK cells by transactivation assay Agonist activity at Gal4-tagged human PPAR-alpha expressed in HEK cells by transactivation assay	[PMID: 27326332]
HEK293	EC₅₀	4511 nM Compound: 3; BMS-711939	Agonist activity at Gal4-tagged human PPAR-gamma expressed in HEK cells by transactivation assay Agonist activity at Gal4-tagged human PPAR-gamma expressed in HEK cells by transactivation assay	[PMID: 27326332]
HepG2	EC₅₀	>1.61 μM Compound: 3; BMS-711939	Agonist activity at full length human PPAR-gamma transfected in human HepG2 cells by luciferase reporter gene assay Agonist activity at full length human PPAR-gamma transfected in human HepG2 cells by luciferase reporter gene assay	[PMID: 27326332]
HepG2	EC₅₀	5 nM Compound: 3; BMS-711939	Agonist activity at full length human PPAR-alpha transfected in human HepG2 cells by luciferase reporter gene assay Agonist activity at full length human PPAR-alpha transfected in human HepG2 cells by luciferase reporter gene assay	[PMID: 27326332]

Chemical Information

CAS No. 1000998-62-8
Molecular Weight 462.86
Formula C₂₂H₂₀ClFN₂O₆
SMILES

O=C(CN(CC1=CC(OCC2=C(C)OC(C3=CC=C(Cl)C=C3)=N2)=CC=C1F)C(OC)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shi Y, et al., Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist. ACS Med Chem Lett. 2016 Apr 4;7(6):590-4. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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BMS711939

All PPAR Isoforms