Bromo-PEG5-azide
Based on 1 Customer Validation
Bromo-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1402411-90-8
- Formula: C12H24BrN3O5
- Molecular Weight:370.24
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1402411-90-8
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Appearance Liquid
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Molecular Weight 370.24
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Formula C12H24BrN3O5
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Color Colorless to light yellow
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SMILES
BrCCOCCOCCOCCOCCOCCN=[N+]=[N-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (270.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (265 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7010 mL | 13.5048 mL | 27.0095 mL | 67.5238 mL |
| 5 mM | 0.5402 mL | 2.7010 mL | 5.4019 mL | 13.5048 mL | |
| 10 mM | 0.2701 mL | 1.3505 mL | 2.7010 mL | 6.7524 mL | |
| 15 mM | 0.1801 mL | 0.9003 mL | 1.8006 mL | 4.5016 mL | |
| 20 mM | 0.1350 mL | 0.6752 mL | 1.3505 mL | 3.3762 mL | |
| 25 mM | 0.1080 mL | 0.5402 mL | 1.0804 mL | 2.7010 mL | |
| 30 mM | 0.0900 mL | 0.4502 mL | 0.9003 mL | 2.2508 mL | |
| 40 mM | 0.0675 mL | 0.3376 mL | 0.6752 mL | 1.6881 mL | |
| 50 mM | 0.0540 mL | 0.2701 mL | 0.5402 mL | 1.3505 mL | |
| 60 mM | 0.0450 mL | 0.2251 mL | 0.4502 mL | 1.1254 mL | |
| 80 mM | 0.0338 mL | 0.1688 mL | 0.3376 mL | 0.8440 mL | |
| 100 mM | 0.0270 mL | 0.1350 mL | 0.2701 mL | 0.6752 mL |
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