1. PROTAC
  2. PROTAC Linkers
  3. Bromo-PEG5-azide

Bromo-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Bromo-PEG5-azide Chemical Structure

Bromo-PEG5-azide Chemical Structure

CAS No. : 1402411-90-8

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Based on 1 publication(s) in Google Scholar

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Description

Bromo-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

370.24

Formula

C12H24BrN3O5

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

BrCCOCCOCCOCCOCCOCCN=[N+]=[N-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (270.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7010 mL 13.5048 mL 27.0095 mL
5 mM 0.5402 mL 2.7010 mL 5.4019 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7010 mL 13.5048 mL 27.0095 mL 67.5238 mL
5 mM 0.5402 mL 2.7010 mL 5.4019 mL 13.5048 mL
10 mM 0.2701 mL 1.3505 mL 2.7010 mL 6.7524 mL
15 mM 0.1801 mL 0.9003 mL 1.8006 mL 4.5016 mL
20 mM 0.1350 mL 0.6752 mL 1.3505 mL 3.3762 mL
25 mM 0.1080 mL 0.5402 mL 1.0804 mL 2.7010 mL
30 mM 0.0900 mL 0.4502 mL 0.9003 mL 2.2508 mL
40 mM 0.0675 mL 0.3376 mL 0.6752 mL 1.6881 mL
50 mM 0.0540 mL 0.2701 mL 0.5402 mL 1.3505 mL
60 mM 0.0450 mL 0.2251 mL 0.4502 mL 1.1254 mL
80 mM 0.0338 mL 0.1688 mL 0.3376 mL 0.8440 mL
100 mM 0.0270 mL 0.1350 mL 0.2701 mL 0.6752 mL
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Bromo-PEG5-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Bromo-PEG5-azide
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