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Cat. No.: HY-148584

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BTK-IN-21

BTK-IN-21 (Compound 12) is a BTK inhibitor with an IC₅₀ of 33 nM. BTK-IN-21 can be used for research in cancer and autoimmunity therapies.

For research use only. We do not sell to patients.

CAS No.: 2170788-98-2
Formula: C₂₆H₂₉N₅OS
Molecular Weight:459.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BTK-IN-21 Chemical Structure

CAS No.: 2170788-98-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

BTK-IN-21 (Compound 12) is a BTK inhibitor with an IC₅₀ of 33 nM. BTK-IN-21 can be used for research in cancer and autoimmunity therapies^[1].

Chemical Information

CAS No. 2170788-98-2
Molecular Weight 459.61
Formula C₂₆H₂₉N₅OS
SMILES

OC1CCC(CC1)NC2=NC(CC3=CC=CC=C3)=CC(NC4=NC5=C(S4)C=C(CC)C=C5)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bavi R, et al. Exploration of Novel Inhibitors for Bruton's Tyrosine Kinase by 3D QSAR Modeling and Molecular Dynamics Simulation. PLoS One. 2016 Jan 19;11(1):e0147190. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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