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Cat. No.: HY-168314

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BTK ligand 11

BTK ligand 11 is a PROTAC target protein ligand that can be used to synthesize BCPyr (HY-142621).

For research use only. We do not sell to patients.

Formula: C₂₂H₂₁F₂N₅O₄
Molecular Weight:457.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BTK ligand 11 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

BTK ligand 11 is a PROTAC target protein ligand that can be used to synthesize BCPyr (HY-142621)^[1].

Chemical Information

Molecular Weight 457.43
Formula C₂₂H₂₁F₂N₅O₄
SMILES

FC1=CC=C(OC2=CC=C(C3=NN([C@H]4CN(C(O)=O)CCC4)C(N)=C3C(N)=O)C=C2)C(F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. James Schiemer, et al. Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes. Nat Chem Biol. 2021 Feb;17(2):152-160. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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