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Cat. No.: HY-175543

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BTK ligand 16

BTK ligand 16 is a BTK ligand that can be used for synthesis of TQ-3959 (HY-175541).

For research use only. We do not sell to patients.

Formula: C₂₁H₂₇N₇O₂
Molecular Weight:409.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BTK ligand 16 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

BTK ligand 16 is a BTK ligand that can be used for synthesis of TQ-3959 (HY-175541)^[1].

Chemical Information

Molecular Weight 409.48
Formula C₂₁H₂₇N₇O₂
SMILES

NC(C1=C(NC2=CC=C(C)C=C2)N=C(N3C[C@H](N4CCN(C)C4=O)CCC3)C=N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ren J, et al. Discovery of TQ-3959 as a Potent and Orally Bioavailable BTK PROTAC Degrader Incorporating a Novel Benzisoxazole-Based CRBN Ligand for the Treatment of B-Cell Malignancies. J Med Chem. 2025 Aug 14;68(15):15960-15979. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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