Bupropion impurity 5
Bupropion impurity 5 is an impurity of Bupropion.
For research use only. We do not sell to patients.
- CAS No.: 1193779-48-4
- Formula: C13H17Cl2NO
- Molecular Weight:274.19
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>100 nM
Compound: 2n
|
Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells
Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells
|
[PMID: 20158204] |
| HEK293 | IC50 |
14 μM
Compound: 2n
|
Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cells
Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cells
|
[PMID: 20158204] |
| SH-SY5Y | IC50 |
19 nM
Compound: 2n
|
Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting
Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting
|
[PMID: 20158204] |
| SH-SY5Y | IC50 |
22 nM
Compound: 2n
|
Antagonist activity at human alpha4beta4 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting
Antagonist activity at human alpha4beta4 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting
|
[PMID: 20158204] |
| SH-SY5Y | IC50 |
3.1 nM
Compound: 2n
|
Antagonist activity at alpha3beta4 nAChR receptor in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting
Antagonist activity at alpha3beta4 nAChR receptor in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting
|
[PMID: 20158204] |
Chemical Information
-
CAS No. 1193779-48-4
-
Molecular Weight 274.19
-
Formula C13H17Cl2NO
-
SMILES
O=C(C=1C=C(Cl)C=C(Cl)C1)C(NC(C)(C)C)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)