CA/MAO-B-IN-1
Based on 1 Customer Validation
CA/MAO-B-IN-1 (Compound 78) is a dual inhibitor for human brain carbonic anhydrases (CA) and Monoamine Oxidase-B (MAO-B), with IC50s of 8.8 and 7.0 nM, respectively. CA/MAO-B-IN-1 reveals a human oral absorption of 71.9% through in silico prediction.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.34%
- CAS. Nr.: 3038173-64-4
- Formel: C17H15NO5S
- Molecular Weight:345.37
-
Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
hCA VB 8.8 nM (IC50) |
hCA VA 9.6 nM (IC50) |
hCA II 41.1 nM (IC50) |
hCA XII 196 nM (IC50) |
hCA I 553.1 nM (IC50) |
CA/MAO-B-IN-1 (12.5-50 μM) reverts formation of ROS, exhibits neuro- and mitochondrial protective effects against Aβ1-42 oligomer-induced neurotoxicity in cells SH-SY5Y[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:SH-SY5Y
-
Concentration:12.5-50 μM
-
Incubation Time:24 h
-
Result:Improved cell viability in SH-SY5Y cells damaged by Aβ1-42.
Chemical Information
-
CAS. Nr. 3038173-64-4
-
Appearance Solid
-
Molecular Weight 345.37
-
Formel C17H15NO5S
-
Color White to off-white
-
SMILES
O=S(C1=CC=C(COC2=CC(O3)=C(C=C2)C=C(C)C3=O)C=C1)(N)=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 175 mg/mL (506.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (272 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8954 mL | 14.4772 mL | 28.9545 mL | 72.3861 mL |
| 5 mM | 0.5791 mL | 2.8954 mL | 5.7909 mL | 14.4772 mL | |
| 10 mM | 0.2895 mL | 1.4477 mL | 2.8954 mL | 7.2386 mL | |
| 15 mM | 0.1930 mL | 0.9651 mL | 1.9303 mL | 4.8257 mL | |
| 20 mM | 0.1448 mL | 0.7239 mL | 1.4477 mL | 3.6193 mL | |
| 25 mM | 0.1158 mL | 0.5791 mL | 1.1582 mL | 2.8954 mL | |
| 30 mM | 0.0965 mL | 0.4826 mL | 0.9651 mL | 2.4129 mL | |
| 40 mM | 0.0724 mL | 0.3619 mL | 0.7239 mL | 1.8097 mL | |
| 50 mM | 0.0579 mL | 0.2895 mL | 0.5791 mL | 1.4477 mL | |
| 60 mM | 0.0483 mL | 0.2413 mL | 0.4826 mL | 1.2064 mL | |
| 80 mM | 0.0362 mL | 0.1810 mL | 0.3619 mL | 0.9048 mL | |
| 100 mM | 0.0290 mL | 0.1448 mL | 0.2895 mL | 0.7239 mL |
CA/MAO-B-IN-1 Related Classifications
HY-163380 Related Classifications
Powered by Bioz