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Cat. No.: HY-P12263

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A5G27

A5G27 is a laminin-derived peptide ligand and CD44 antagonist that binds to CD44, CD44v3, and CD44v6, driving receptor-mediated endocytosis and internalization into CD44-expressing cells. A5G27 alleviates mechanical hyperalgesia induced by substances such as carrageenan and Hyaluronidase. A5G27 exhibits antitumor activity. A5G27 can be used in research on cancer, inflammatory pain, and wound healing.

For research use only. We do not sell to patients.

CAS No.: 288307-57-3
Formula: C₇₇H₁₂₀N₁₈O₁₇
Molecular Weight:1569.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

A5G27 Chemical Structure

CAS No.: 288307-57-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

The A5G27 peptide (13 mer) binds to CD44 isoforms on B16-F10 melanoma cells, and its adhesion is decreased by heparan sulfate and chondroitin sulfate^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A5G27 (1 μg; intradermal injection) significantly alleviates mechanical hyperalgesia induced by Hyaluronidase (HY-107910), low molecular weight hyaluronic acid (LMWH), carrageenan, and high molecular weight hyaluronic acid (HMWH)^[3]^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats (adult male, 220-400 g, Charles River Laboratories)^[3]
Dosage:

1 μg
Administration:

i.d.; single dose
Result:

Significantly attenuated the mechanical hyperalgesia induced by hyaluronidase (5 U).
Significantly attenuated the mechanical hyperalgesia induced by LMWH.
Significantly attenuated the magnitude of carrageenan-induced mechanical hyperalgesia.
Attenuated HMWH-induced anti-PGE2 hyperalgesia, with a significant difference compared to vehicle+HMWH-treated group.

Related Protocols :

Chemical Information

CAS No. 288307-57-3
Molecular Weight 1569.89
Formula C₇₇H₁₂₀N₁₈O₁₇
Sequence

Arg-Leu-Val-Ser-Tyr-Asn-Gly-Ile-Ile-Phe-Phe-Leu-Lys
Sequence Shortening

RLVSYNGIIFFLK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pesarrodona M, et al. Intracellular targeting of CD44+ cells with self-assembling, protein only nanoparticles. International journal of pharmaceutics. 2014 Oct 01;473(1-2):286-95.

[2]. Turley EA, et al. RHAMM and CD44 peptides-analytic tools and potential drugs. Frontiers in bioscience (Landmark edition). 2012 Jan 01;17(5):1775-94.

[3]. Ferrari LF, et al. Extracellular matrix hyaluronan signals via its CD44 receptor in the increased responsiveness to mechanical stimulation. Neuroscience. 2016 Jun 02;324:390-8.

[4]. Pesarrodona M, et al. Intrinsic functional and architectonic heterogeneity of tumor-targeted protein nanoparticles. Nanoscale. 2017 May 18;9(19):6427-6435.

[5]. Bonet IJ. Mechanisms mediating high-molecular-weight hyaluronan-induced antihyperalgesia. Journal of Neuroscience. 2020 Aug 19;40(34):6477-88.

[6]. Milošević N, et al. Endothelial Cell Adhesion Molecules- (un)Attainable Targets for Nanomedicines. Frontiers in medical technology. 2022;4:846065.

[7]. Kulkarni N, et al. Peptide-Chitosan Engineered Scaffolds for Biomedical Applications. Bioconjugate chemistry. 2021 Mar 17;32(3):448-465.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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