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Botensilimab

(Synonyms: AGEN 1181)
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Based on 1 Customer Validation

Botensilimab (AGEN 1181), a human anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) monoclonal antibody, is an innate and adaptive immune activator. Botensilimab can be used for the research of cancer.

For research use only. We do not sell to patients.

  • Purity: 99.00%
  • CAS No.: 2408310-37-0
  • Molecular Weight:144.54 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Botensilimab
  • Experimental Validation Results for Botensilimab
  • Experimental Validation Results for Botensilimab
  • Experimental Validation Results for Botensilimab
  • Botensilimab Chemical Structure
    Botensilimab Chemical Structure
CAS No.: 2408310-37-0
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Botensilimab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human CTLA-4 Protein (His Tag) can bind Botensilimab. The EC50 for this effect is 2.04 ng/mL.

  • 1/16

    Loaded Botensilimab on AHC2 biosensor, can bind CTLA-4 Protein, Human (HEK293, His, HY-P70684) with an affinity constant of 8.815E-10 M as determined in BLI assay.

  • 1/16

    Flow Cytometry analysis of Raji cells labelling CTLA4 (red) with Botensilimab (HY-P99484). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Botensilimab Chemical Structure
    1/16
  • Botensilimab
  • Immobilized Human CTLA-4 Protein (His Tag) can bind Botensilimab. The EC50 for this effect is 2.04 ng/mL.
  • Loaded Botensilimab on AHC2 biosensor, can bind CTLA-4 Protein, Human (HEK293, His, HY-P70684) with an affinity constant of 8.815E-10 M as determined in BLI assay.
  • Flow Cytometry analysis of Raji cells labelling CTLA4 (red) with Botensilimab (HY-P99484). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).