CL-242817
CL-242817 is an orally available angiotensin converting enzyme (ACE) inhibitor. CL-242817 inhibits the conversion of angiotensin I to angiotensin II and has blood pressure lowering activity. CL-242817 can also improve Monocrotaline (HY-N0750) induced lung injury. CL-242817 can be used in the study of pulmonary fibrosis and hypertension-related diseases.
For research use only. We do not sell to patients.
- CAS No.: 86709-48-0
- Formula: C18H21NO5S
- Molecular Weight:363.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CL-242817 effectively inhibits rabbit lung ACE in vitro (IC50=54.9 nM), angiotensin I (Al) induced contraction of isolated guinea pig ileum (IC50=0.82 pM), and enhances bradykinin (BK) induced contraction of isolated guinea pig ileum (EC50=0.383 pM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 86709-48-0
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Molecular Weight 363.43
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Formula C18H21NO5S
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SMILES
O=C([C@H]1N(CCC1)C([C@H]([C@@H](C(C2=CC=CC=C2)=O)SC(C)=O)C)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CL-242817 Related Classifications
HY-129213 Related Classifications
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