Cat. No.: HY-W015410

Disodium succinate

11 Cited Publications

Customer Review

Based on 11 publication(s) in Google Scholar

Disodium succinate is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Disodium succinate is an intermediate product of the tricarboxylic acid cycle. Disodium succinate is an important platform chemical. Disodium succinate can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields.

For research use only. We do not sell to patients.

Purity: 99.86%
CAS No.: 150-90-3
Formula: C₄H₄Na₂O₄
Molecular Weight:162.05

Storage:

Store at room temperature, keep dry and cool.

In solvent -80°C, 1 year , -20°C, 6 months

Disodium succinate Chemical Structure

CAS No.: 150-90-3

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Use of MCE Products

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (11)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vivo

Succinic acid (3-6 mg/kg; p.o.; Single dose) has anti-anxiety effects in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Elevated plus-maze test mice model^[3]
Dosage:

3 mg/kg, 6 mg/kg
Administration:

Oral gavage (p.o.); Single dose
Result:

At doses of 3.0 and 6.0 mg/kg significantly increased the percentage of mice that entered the open arm and the percentage of time that the open arm stayed.

Animal Model:

Food intake mice model ^[3]
Dosage:

3 mg/kg, 6 mg/kg, 12 mg/kg
Administration:

Intraperitoneal injection (i.p.); Single dose
Result:

Significantly increased the mice's food intake within 5 minutes after administration.

Animal Model:

Stress-induced hyperthermia test mice model^[3]
Dosage:

1.5 mg/kg, 3 mg/kg, 6 mg/kg
Administration:

Oral gavage (p.o.); Single dose
Result:

Inhibited stress-induced hyperthermia at a dose of 1.5 mg/kg.

Chemical Information

CAS No. 150-90-3
Appearance Solid
Molecular Weight 162.05
Formula C₄H₄Na₂O₄
Color White to off-white
SMILES

O=C(O[Na])CCC(O[Na])=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Publications (11)

All RT-PCRIn Vivo Efficacy StudyWBHistological Imaging/StainingCell Imaging/Staining

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Cell Host Microbe

Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer. [Abstract]

2023 May 10;31(5):781-797.e9. PMID: 37130518

Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]

Relative mRNA expression of IFN-b and cGAS in LoVo cells treated with succinic acid (0.5 mM;24 h) or F. nucleatum supernatant

Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]

Representative immunoblotting of cGAS expression in HT29 and LoVo cells treated with succinic acid (0.5 mM; 24 h).

Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]

Relative mRNA expression of CCL5 and CXCL10 in LoVo cells treated with succinic acid (0.5 mM; 24 h) or F. nucleatum supernatant.

Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]

Relative expression of candidate transcriptional regulation elements in LoVo cells treated with succinic acid (0.5 mM; 24 h).

Disodium succinate purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2023 May 10;31(5):781-797.e9. [Abstract]

Relative cGAS mRNA expression in LoVo cells transfected with EZH2 siRNA, then treated with succinic acid (0.5 mM; 24 h).
Acta Pharm Sin B

Intestinal epithelial cell NCoR deficiency ameliorates obesity and metabolic syndrome. [Abstract]

2024 Dec;14(12):5267-5285. PMID: 39807334

Disodium succinate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Dec;14(12):5267-5285. [Abstract]

After lowering the concentration of Disodium succinate from 2.5% to 2% in water for 2 weeks, the body weight of the WT mice rebounded, whereas that of the IKO mice remained the same. Changes in body weight after the administration of sodium succinate to WT and IKO mice (fed with HFD for 24 week).

Disodium succinate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Dec;14(12):5267-5285. [Abstract]

Oxygen consumption rate and energy expenditure (heat production) of HFD-fed WT and IKO mice after 4 weeks of Disodium succinate administration (2.5%), as measured by CLAMS.

Disodium succinate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Dec;14(12):5267-5285. [Abstract]

Oral glucose tolerance tests (OGTTs) after 4 weeks of 2.5% Disodium succinate administration to HFD-fed (24-week-old) WT and IKO mice.
Cell Mol Gastroenterol Hepatol

Microbial Monotherapy With Leuconostoc sp LB-P8 Improves Inflammation and Fibrosis in Mouse Primary Sclerosing Cholangitis by Inhibiting Transforming Growth Factor β1/SMAD Signaling. [Abstract]

2026 Apr 15;20(8):101789. PMID: 41997362
Stem Cell Res Ther

From inflammation to healing: the crucial role of GPR91 activation and SDH inhibition in chronic diabetic wound recovery. [Abstract]

2025 Jul 23;16(1):399. PMID: 40702577
Cell Rep

Streptococcus anginosus-generated succinate promotes the progression of gastric cancer via the succinate/SUCNR1/ABRAXAS1 axis. [Abstract]

2026 Feb 25;45(3):117047. PMID: 41746808
Inflamm Res

PGC1α alleviates M1 macrophage polarization through dual regulation of succinate metabolism and TRAF5 expression to mitigate TLR4/NF-κB-driven inflammatory cascades and myocardial ischemia/reperfusion injury. [Abstract]

2025 Nov 6;74(1):156. PMID: 41196309
Oncol Res

SDHA Deficiency in Hepatocellular Carcinoma Promotes Tumor Progression through Succinate-Induced M2 Macrophage Polarization. [Abstract]

2026 Jan 19;34(2):25. PMID: 41613800
Water Air Soil Pollut

232, 473 (2021).
J Proteomics

Global proteomic analysis reveals lysine succinylation is involved in the pathogenesis of hypertrophic scar. [Abstract]

2024 Apr 30:298:105155. PMID: 38460743
Research Square Print

December 9th, 2022.

Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.

Disodium succinate (40 mM; 48 h) in ovaries were stripped from 21-day-old female KM mice elevated the global Ksuc level of mouse ovary cultured in vitro.

Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.

Disodium succinate (40 mM; 48 h) in ovaries were stripped from 21-day-old female KM mice showed the GCs in the ovaries of the succinate administration group were more sparsely arranged around the follicles compared to the control group.

Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.

Disodium succinate (40 mM; 48 h) in ovaries of 21-day-old female KM mice showed an increased staining in ovarian cells in the succinate group as compared with the control group.

Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.

Disodium succinate (40 mM; 48 h) in ovaries of 21-day-old female KM mice verified that B-cell lymphoma-2 (Bcl-2) significantly decreased and Cleaved-caspase 3 significantly increased in succinate-treated ovaries, whereas BCL2-associated X (Bax) and proliferating cell nuclear antigen (PCNA) did not change significantly in mRNA levels.

Disodium succinate purchased from MedChemExpress. Usage Cited in: Research Square Print. December 9th, 2022.

Disodium succinate (40 mM; 48 h) in ovaries of 21-day-old female KM mice verified that B-cell lymphoma-2 (Bcl-2) significantly decreased and Cleaved-caspase 3 significantly increased in succinate-treated ovaries, whereas BCL2-associated X (Bax) and proliferating cell nuclear antigen (PCNA) did not change significantly in protein levels.

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (617.09 mM)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.1709 mL

30.8547 mL

61.7093 mL

5 mM

1.2342 mL

6.1709 mL

12.3419 mL

10 mM

0.6171 mL

3.0855 mL

6.1709 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (617.09 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang YJ, et al. Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). J Zhejiang Univ Sci B. 2012 Feb;13(2):103-10. [Content Brief]

[2]. Johns A T. The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation[J]. The Biochemical journal, 1948, 42(1): ii. [Content Brief]

[3]. Chen SW, Xin Q, Kong WX, Min L, Li JF. Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003 Nov 7;73(25):3257-64. doi: 10.1016/j.lfs.2003.06.017. PMID: 14561530. [Content Brief]

[4]. Xu J, et al. Microbial succinic acid, its polymer poly (butylene succinate), and applications[J]. Plastics from bacteria: Natural functions and applications, 2010: 347-388.

[5]. Bechthold I, et al. Succinic acid: a new platform chemical for biobased polymers from renewable resources[J]. Chemical Engineering & Technology: Industrial Chemistry‐Plant Equipment‐Process Engineering‐Biotechnology, 2008, 31(5): 647-654.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	6.1709 mL	30.8547 mL	61.7093 mL	154.2734 mL
	5 mM	1.2342 mL	6.1709 mL	12.3419 mL	30.8547 mL
	10 mM	0.6171 mL	3.0855 mL	6.1709 mL	15.4273 mL
	15 mM	0.4114 mL	2.0570 mL	4.1140 mL	10.2849 mL
	20 mM	0.3085 mL	1.5427 mL	3.0855 mL	7.7137 mL
	25 mM	0.2468 mL	1.2342 mL	2.4684 mL	6.1709 mL
	30 mM	0.2057 mL	1.0285 mL	2.0570 mL	5.1424 mL
	40 mM	0.1543 mL	0.7714 mL	1.5427 mL	3.8568 mL
	50 mM	0.1234 mL	0.6171 mL	1.2342 mL	3.0855 mL
	60 mM	0.1028 mL	0.5142 mL	1.0285 mL	2.5712 mL
	80 mM	0.0771 mL	0.3857 mL	0.7714 mL	1.9284 mL
	100 mM	0.0617 mL	0.3085 mL	0.6171 mL	1.5427 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Disodium succinate

11 Cited Publications

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Disodium succinate

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Publications Citing Use of MedChemExpress (MCE) Disodium succinate

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (11)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Disodium succinate Related Classifications

Cat. No.: HY-W015410