DSPE-PEG2000-FPBA

DSPE-PEG2000-FPBA is primarily used for tumor-targeting and glucose-responsive delivery research.
Structural composition and function of each component:
(1) DSPE: 1,2-distearate-sn-glycerol-3-phosphoethanolamine, containing two saturated C18 stearoyl chains, is an amphiphilic phospholipid. As a lipid anchoring group, it can stably insert into the lipid bilayer of liposomes or lipid nanoparticles, anchoring the entire molecule to the carrier surface;
(2) PEG2000: Polyethylene glycol with a molecular weight of approximately 2000 Da, as a hydrophilic spacer arm, can enhance the water solubility and steric hindrance of the molecule, improve the stability of the carrier and prolong its circulation time in vivo, while extending the terminal ligand away from the carrier surface, which is beneficial for the recognition and binding of ligand and receptor;
(3) Fluorophenylboronic acid: Fluorophenylboronic acid is a fluorinated derivative of phenylboronic acid. The introduction of fluorine atoms enhances the binding ability of boric acid and sialic acid and other ortho-dihydroxy structures, and has both tumor-targeting and glucose-responsive properties.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.