RXRB - retinoid X receptor beta Gene

Also Known as NR2B2; DAUDI6; RCoR-1; RXRbeta; H-2RIIBP; RXR-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6257

About RXRB

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,193,588-33,200,853 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 215 orthologues and 11 paralogues. Ubiquitous expression in thyroid (RPKM 13.3), spleen (RPKM 12.9) and 25 other tissues.

Summary

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

RXRB Products (3)

mRNA	Protein	Name
NM_001270401.2	NP_001257330.1	retinoic acid receptor RXR-beta isoform 1
NM_001291989.2	NP_001278918.1	retinoic acid receptor RXR-beta isoform 3
NM_021976.5	NP_068811.1	retinoic acid receptor RXR-beta isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12767074	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12767074	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	1662118	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1662118	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12767074	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	25416956	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7990953	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RXRB Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
500
533 a.a.

Protein Preferred Names	Protein Names
retinoic acid receptor RXR-beta	MHC class I promoter binding protein

RXRB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RXRB	P28702	NR1H2	Homo sapiens	F1D8P7	Y2H Prey Pooling	32296183
Intra	RXRB	P28702	NR1H2	Homo sapiens	F1D8P7	Y2H Array	32296183
Intra	RXRB	P28702	RARA	Homo sapiens	P10276-2	Y2H Prey Pooling	26871637
Intra	RXRB	P28702	RARA	Homo sapiens	P10276-2	Y2H Array	26871637
Intra	RXRB	P28702	RARA	Homo sapiens	P10276-2	Validated Y2H	26871637
Intra	RXRB	P28702	CACNA1B	Homo sapiens	Q00975	Display Tech	20195357
Intra	RXRB	P28702	NR1H3	Homo sapiens	Q13133-3	Y2H Array	26871637
Intra	RXRB	P28702	NR1H3	Homo sapiens	Q13133-3	Validated Y2H	32296183
Intra	RXRB	P28702	NR1H3	Homo sapiens	Q13133-3	Y2H Prey Pooling	26871637
Intra	RXRB	P28702	NR1H3	Homo sapiens	Q13133-3	Validated Y2H	26871637
Intra	RXRB	P28702	NR1H4	Homo sapiens	Q96RI1-1	Y2H Prey Pooling	26871637
Intra	RXRB	P28702	NR1H4	Homo sapiens	Q96RI1-1	Validated Y2H	26871637
Intra	RXRB	P28702	NR1H4	Homo sapiens	Q96RI1-1	Y2H Array	26871637
Intra	RXRB	P28702	NR1H4	Homo sapiens	Q96RI1-1	Y2H Prey Pooling	32296183
Intra	RXRB	P28702	NR1H4	Homo sapiens	Q96RI1-1	Validated Y2H	32296183
Intra	RXRB	P28702	NR1H4	Homo sapiens	Q96RI1-1	Y2H Array	32296183
Intra	RXRB	P28702	RARG	Homo sapiens	P13631	Y2H Array	32296183
Intra	RXRB	P28702	RARG	Homo sapiens	P13631	Y2H Prey Pooling	32296183
Intra	RXRB	P28702	SPOPL	Homo sapiens	Q6IQ16	Validated Y2H	32296183
Intra	RXRB	P28702	SPOPL	Homo sapiens	Q6IQ16	Y2H Array	32296183
Intra	RXRB	P28702	SPOPL	Homo sapiens	Q6IQ16	Y2H Prey Pooling	32296183
Intra	RXRB	P28702	RARA	Homo sapiens	P10276	Validated Y2H	26871637
Intra	RXRB	P28702	RARA	Homo sapiens	P10276	Y2H Array	31515488
Intra	RXRB	P28702	RARA	Homo sapiens	P10276	Y2H Array	26871637
Intra	RXRB	P28702	RARA	Homo sapiens	P10276	Y2H Array	29892012
Intra	RXRB	P28702	RARA	Homo sapiens	P10276	Y2H Prey Pooling	26871637
Intra	RXRB	P28702	RARA	Homo sapiens	P10276	Y2H	21988832
Intra	RXRB	P28702	NR3C1	Homo sapiens	P04150	Pull Down	20211142
Intra	RXRB	P28702	MYG1	Homo sapiens	Q9HB07	Validated Y2H	32296183
Intra	RXRB	P28702	MYG1	Homo sapiens	Q9HB07	Y2H Array	32296183
Intra	RXRB	P28702	MYG1	Homo sapiens	Q9HB07	Y2H Prey Pooling	32296183
Intra	RXRB	P28702	NR1H3	Homo sapiens	Q13133	Y2H Array	25416956
Intra	RXRB	P28702	PPARG	Homo sapiens	P37231	Pull Down	20211142
Intra	RXRB	P28702	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	RXRB	P28702	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	RXRB	P28702	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	RXRB	P28702	RARB	Homo sapiens	P10826-2	Validated Y2H	26871637
Intra	RXRB	P28702	RARB	Homo sapiens	P10826-2	Y2H Array	26871637
Intra	RXRB	P28702	RARB	Homo sapiens	P10826-2	MAPPIT	25416956
Intra	RXRB	P28702	RARB	Homo sapiens	P10826-2	Y2H Array	25416956
Intra	RXRB	P28702	RARB	Homo sapiens	P10826-2	Y2H Prey Pooling	26871637

Cross: Cross-species interaction Intra: Intraspecies interaction

RXRB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87060	Retinoid X Receptor beta/RXRB Antibody (YA6753)	WB, ICC/IF, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis
Vasculitis	Angiitis Autoimmune Vasculitis Systemic Vasculitis Vasculitis, Autoimmune
Otospondylomegaepiphyseal Dysplasia, Autosomal Dominant	Weissenbacher-Zweymuller Syndrome Wzs Pierre Robin Syndrome With Fetal Chondrodysplasia OSMEDA Weissenbacher-Zweymüller Syndrome Heterozygous Osmed Stickler Syndrome, Type 3 Osmed, Heterozygous Pierre Robin Syndrome With Fetal Chondrodysplasia Stickler Syndrome, Nonocular Type, Formerly Stickler Syndrome, Type Iii, Formerly Stl3, Formerly Piere-Robin Syndrome Pierre Robin Malformation Heterozygous Otospondylomegaepiphyseal Dysplasia Autosomal Dominant Otospondylomegaepiphyseal Dysplasia Ad Osmed Stickler Syndrome Type 3 Stickler Syndrome, Non-Ocular Type Stickler-Like Syndrome Stickler Syndrome 3 Stickler Syndrome Non-Ocular Type Stickler Syndrome Type Iii Stl3 Weissenbacher-Zweymueller Syndrome Stickler Syndrome, Type Iii Pierre Robin Syndrome Dysplasia, Otospondylomegaepiphyseal, Autosomal Dominant
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12362	RXRB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-160212	JP3000	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RXRB	VGNC	VGNC:45818
Macaca mulatta	RXRB	VGNC	VGNC:76952
Mus musculus	RXRB	MGD	MGI:98215
Bos taurus	RXRB	VGNC	VGNC:34231
Rattus norvegicus	RXRB	RGD	RGD:3611
Others	RXRB	NCBI