SLC22A1 - solute carrier family 22 member 1 Gene
Also Known as OCT1; HOCT1; oct1_cds
Species: Homo sapiens
About SLC22A1
This gene has 7 transcripts (splice variants), 495 orthologues and 22 paralogues. Restricted expression toward liver (RPKM 121.5).
Summary
Polyspecific organic cation transporters in the liver, kidney, intestine, and Other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]
SLC22A1 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_003057.3 | NP_003048.1 | solute carrier family 22 member 1 isoform a |
| NM_153187.2 | NP_694857.1 | solute carrier family 22 member 1 isoform b |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in apical plasma membrane |
IDA
IDA: Inferred from direct assay
|
15817714 | GOA |
| located in basal plasma membrane |
IDA
IDA: Inferred from direct assay
|
35307651 | GOA |
| located in basolateral plasma membrane |
IDA
IDA: Inferred from direct assay
|
12719534 | GOA |
| located in lateral plasma membrane |
IDA
IDA: Inferred from direct assay
|
16263091 | GOA |
SLC22A1 Protein Structure
Sugar_tr: Sugar (and other) transporter (144 - 523)
- 0
- 100
- 200
- 300
- 400
- 500
- 554 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
solute carrier family 22 member 1 |
|
SLC22A1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SLC22A1 | O15245 | CERS2 | Homo sapiens | Q96G23 | 11543633 | |
|
Intra
|
SLC22A1 | O15245 | CERS2 | Homo sapiens | Q96G23 | 21988832 | |
|
Intra
|
SLC22A1 | O15245 | SMIM3 | Homo sapiens | Q9BZL3 | 32296183 |
SLC22A1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82681 | SLC22A1/OCT1 Antibody (YA2426) | WB, FC | Human |
| HY-P83828 | SLC22A1/OCT1 Antibody (YA3525) | FC, ELISA | Human |
| HY-P83828A | SLC22A1/OCT1 Antibody (YA3525)(PBS only) | FC, ELISA | Human |
| HY-P85303 | SLC22A1/OCT1 Antibody (YA4995) | WB; FC | Human |
| HY-P85379 | SYK Antibody (YA5071) | WB, ELISA | Human |
| HY-P85379A | SYK Antibody (YA5071)(PBS only) | WB, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cholestasis |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Chromosome 17q23.1-Q23.2 Deletion Syndrome |
|
|
| Diabetes Mellitus |
|
|
| Thrombocytopenia |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS13061 | SLC22A1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS19841 | Slc22a1 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS26339 | Slc22a1 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | SLC22A1 | VGNC | VGNC:77417 |
| Rattus norvegicus | SLC22A1 | RGD | RGD:3224 |
| Mus musculus | SLC22A1 | MGD | MGI:108111 |
| Bos taurus | SLC22A1 | VGNC | VGNC:34719 |
| Canis familiaris | SLC22A1 | VGNC | VGNC:46270 |
| Felis catus | SLC22A1 | VGNC | VGNC:97629 |
| Others | SLC22A1 | NCBI |
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