NUAK1 - NUAK family kinase 1 Gene

Also Known as ARK5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9891

About NUAK1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:106,063,345-106,138,954 (from NCBI)

This gene has 4 transcripts (splice variants), 257 orthologues and 17 paralogues. Broad expression in brain (RPKM 19.6), skin (RPKM 9.2) and 19 other tissues.

Summary

Enables p53 binding activity and protein serine/threonine kinase activity. Involved in several processes, including protein phosphorylation; regulation of cellular senescence; and regulation of myosin-light-chain-phosphatase activity. Located in cytoplasm; microtubule cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

NUAK1 Products (1)

mRNA Protein Name
NM_014840.3 NP_055655.1 NUAK family SNF1-like kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables p53 binding IPI
IPI: Inferred from physical interaction
21317932 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16306228 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
19927127 GOA
Biological Process GO Annotation Evidence References Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
25329316 GOA
involved in regulation of cell adhesion IDA
IDA: Inferred from direct assay
20354225 GOA
involved in regulation of cellular senescence IDA
IDA: Inferred from direct assay
19927127 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21317932 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21317932 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUAK1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (55 - 305)

  • 0
  • 200
  • 400
  • 600
  • 661 a.a.
Protein Preferred Names Protein Names

NUAK family SNF1-like kinase 1

  • AMP-activated protein kinase family member 5

  • AMPK-related protein kinase 5

  • NUAK family, SNF1-like kinase, 1

  • omphalocele kinase 1

NUAK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NUAK1 O60285 SRRM2 Homo sapiens Q9UQ35
Anti Tag CoIP
25852190
Intra
NUAK1 O60285 SRRM2 Homo sapiens Q9UQ35
Pull Down
32707033
Intra
NUAK1 O60285 USP9X Homo sapiens Q93008
TAP
16306228
Intra
NUAK1 O60285 USP9X Homo sapiens Q93008
Pull Down
32707033
Intra
NUAK1 O60285 TP53 Homo sapiens P04637
Protein Kinase Assay
21317932
Intra
NUAK1 O60285 TP53 Homo sapiens P04637
CH-IP
21317932
Cross: Cross-species interaction Intra: Intraspecies interaction

NUAK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89898 NUAK1/ARK5 Antibody (YA9242) WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA human

Related Diseases

Diseases Alias
Omphalocele

  • Omphalocoele

  • Congenital Omphalocele

  • Exomphalos

  • Exumbilication
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Endometrial Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Endometrium
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12624 Narazaciclib Inhibitor 98.66% Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12334 HTH-01-015 Inhibitor 99.10% Unkown
HY-15802 WZ4003 Inhibitor 98.22% Unkown
HY-120877 MRT199665 Inhibitor 99.85% Unkown
HY-153103 LRRK2/NUAK1/TYK2-IN-1 Inhibitor / Unkown
HY-153058 LRRK2-IN-8 Inhibitor / Unkown
HY-182743 OICR19451 Inhibitor / Unkown
HY-178171 ARUK2010489 Inhibitor 96.64% Unkown
HY-182361 NUAK1-IN-3 Inhibitor / Unkown
HY-178168 ARUK2010694 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NUAK1 VGNC VGNC:75403
Rattus norvegicus NUAK1 RGD RGD:1309956
Bos taurus NUAK1 VGNC VGNC:50006
Mus musculus NUAK1 MGD MGI:1925226
Canis familiaris NUAK1 VGNC VGNC:54977
Others NUAK1 NCBI