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Cat. No.: HY-189034

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NE97221

NE97221 is a nitrogen-containing bisphosphonate analog of Risedronic acid (HY-B0148) and an FPPS inhibitor. NE97221 has low affinity for hydroxyapatite and also exhibits weak mineral affinity in hydroxyapatite elution experiments. NE97221 can be used in osteoporosis-related research.

For research use only. We do not sell to patients.

CAS No.: 75755-07-6
Formula: C₇H₁₁NO₆P₂
Molecular Weight:267.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (289 KB)

NE97221 Chemical Structure

CAS No.: 75755-07-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

NE97221 inhibits human FPPS, with an initial IC₅₀ of 258.8 nM and a final IC₅₀ of 30.4 nM after 10 min of preincubation^[1].
NE97221 is an analog of Risedronic acid (HY-B0148) and exhibits lower binding affinity for hydroxyapatite than Risedronic acid^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 75755-07-6
Molecular Weight 267.11
Formula C₇H₁₁NO₆P₂
SMILES

O=P(O)(C(P(O)(O)=O)CC1=NC=CC=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (289 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fernández D, et al. Human farnesyl pyrophosphate synthase inhibition by nitrogen bisphosphonates: a 3D-QSAR study. Journal of Computer-Aided Molecular Design, 2013, 27: 739-754.

[2]. Zielińska M, et al. Comparative analysis of risedronate and its regioisomers synthesized via microwave-assisted method: bone affinity, cytotoxicity, permeability, and therapeutic potential. Pharmacological Reports. 2025 Apr;77(2):517-31.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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