CLEC2D
CLEC2D, commonly known as LLT1 or OCIL, is the natural ligand of the NK-cell receptor CD161 (NKR-P1A). This type II transmembrane C-type lectin is expressed on dendritic cells, activated B cells, and some tumor cells, where it dampens NK-cell cytotoxicity and IFN-γ release through inhibitory CD161 signaling. Structurally related to the NKG2 family, LLT1 has been studied in viral infection, autoimmune disease, and tumor immune evasion, and blocking antibodies show promise for enhancing antitumor immunity. Within this receptor family it is distinctive for functioning mainly as a ligand for a lymphoid receptor rather than as a pathogen sensor. Recombinant CLEC2D is used to dissect CD161-mediated immune checkpoints.
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CLEC2D Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
