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Cat. No.: HY-28911

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2-Hydroxyacetaldehyde

2-Hydroxyacetaldehyde acts as a ribonucleotide synthesis precursor and a LDL modifier. 2-Hydroxyacetaldehyde specifically targets lysine residues of high-affinity LDL receptors and their apolipoproteins. By blocking the ε-amino groups of apolipoproteins, 2-Hydroxyacetaldehyde prevents receptor recognition, thereby reducing LDL degradation by macrophages. 2-Hydroxyacetaldehyde generates modified LDL, which serves as a probe for investigating non-receptor-dependent catabolic pathways.

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CAS No.: 141-46-8
Formule: C₂H₄O₂
Masse moléculaire:60.05

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Please store the product under the recommended conditions in the Certificate of Analysis.

2-Hydroxyacetaldehyde Chemical Structure

CAS No.: 141-46-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- In Vitro
Chemical Information
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Activité biologique

Description

In Vitro

2-Hydroxyacetaldehyde (80 mM; 2.5-21 h at 37°C) rapidly modifies lysine residues on human LDL^[1].
2-hydroxyacetaldehyde-modified human LDL (100 μg/mL) does not compete with native LDL for LDL receptors on cultured normal human fibroblasts, resulting in a degradation rate of 94% relative to the no-competitor control^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 141-46-8
Masse moléculaire 60.05
Formule C₂H₄O₂
SMILES

OCC=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Shepherd J, Packard C J. Receptor-independent low-density lipoprotein catabolism[M]//Methods in enzymology. Academic Press, 1986, 129: 566-590.

[2]. Harman CE, et al. Atmospheric production of glycolaldehyde under hazy prebiotic conditions. Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. 2013 Apr;43(2):77-98. [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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