Cat. No.: HY-19707

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4μ8C

(Synonyms: IRE1 Inhibitor III)

74 Cited Publications

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Based on 74 publication(s) in Google Scholar

4μ8C (IRE1 Inhibitor III) is a small-molecule inhibitor of IRE1α.

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Pureté: 99.95%
CAS No.: 14003-96-4
Formule: C₁₁H₈O₄
Masse moléculaire:204.18

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 1 year , -20°C, 6 months

4μ8C Chemical Structure

CAS No.: 14003-96-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (74)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

4μ8C (IRE1 Inhibitor III) is a small-molecule inhibitor of IRE1α.

Cellular Effect

Cell Line	Type	Value	Description	References
JeKo-1	IC₅₀	1.57 μM Compound: 5, 4mu8C	Inhibition of XBP-1s expression in human Jeko cells after 24 hrs by immunoblotting analysis Inhibition of XBP-1s expression in human Jeko cells after 24 hrs by immunoblotting analysis	[PMID: 24749861]
Sf21	IC₅₀	206 nM Compound: 5, 4mu8C	Inhibition of human recombinant puritin-His-tagged IRE-1 RNase expressed in SF21 cells using XBP-1 RNA stem loop as substrate incubated for 30 mins prior to substrate addition measured after 2 hrs by FRET-suppression assay Inhibition of human recombinant puritin-His-tagged IRE-1 RNase expressed in SF21 cells using XBP-1 RNA stem loop as substrate incubated for 30 mins prior to substrate addition measured after 2 hrs by FRET-suppression assay	[PMID: 24749861]

In Vitro

When applies to the media of ER stressed cultured cells, 4μ8C (IRE1 Inhibitor III) inhibits Xbp1 splicing in a concentration-dependent manner. 4μ8C dissociates slowly from IRE1, but ishout of inhibitor leads to rapid recovery of Xbp1 splicing in cells^[1].The IRE1 endoribonuclease inhibitor 4μ8c prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production^[2]. The inositol-requiring enzyme 1α (IRE1α) is a serine-threonine kinase that plays crucial roles in activating the unfolded protein response. 4μ8C treatment dramatically inhibits IL-4 production by CD4⁺ T cells under Th0 conditions because both the IL-4 levels in the culture supernatant and the percentage of IL-4 positive cells are reduced by 4μ8C treatment. In addition, both IL-5 and IL-13 production are significantly reduced upon treatment with 4μ8C^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

4μ8c (IRE1 Inhibitor III) (i.p. injection; 10 mg/kg/day for 4 more weeks) leads to a significant reduction (45.2%) in atherosclerotic lesion area in en face aorta preparations. 4μ8c can effectively mitigate plaque development in mice^[4].
4μ8C (orally; 10, 50, or 100 mg/kg) suppresses passive cutaneous anaphylaxis (PCA) in mice (ED50 = 25.1 mg/kg)^[5].
4μ8C reverses the ER stress-dependent loss of several known RIDD targets, with an EC₅₀ of approximately 4 μM, approximating that of inhibition of XBP1 target gene activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ApoE^-/- mice^[4]
Dosage:

10 mg/kg
Administration:

I.p. injection; daily; for 4 more weeks
Result:

Led to a significant reduction (45.2%) in atherosclerotic lesion area in en face aorta preparations.

Chemical Information

CAS No. 14003-96-4
Appearance Solid
Masse moléculaire 204.18
Formule C₁₁H₈O₄
Color Light yellow to yellow
SMILES

O=CC1=C(O)C=CC2=C1OC(C=C2C)=O
Synonyms

IRE1 Inhibitor III
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	1 year
	-20°C	6 months

Publications (74)

All 2D/3D Cell Culture and DifferentiationRT-PCRWB

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Journal Impact Factor

Signal Transduct Target Ther

Malate initiates a proton-sensing pathway essential for pH regulation of inflammation. [Abstract]

2024 Dec 30;9(1):367. PMID: 39737965
Nature

The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells. [Abstract]

2023 Apr;616(7956):348-356. PMID: 37020026
Immunity

Unfolded protein response transcription factor XBP1 suppresses necroptosis-induced colitis by reinforcing the mucus barrier. [Abstract]

2025 Aug 22:S1074-7613(25)00332-2. PMID: 40865520

4μ8C purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Aug 22:S1074-7613(25)00332-2. [Abstract]

Representative images of mouse colon organoids treated with G'9668 or 4μ8C (10 μM) for 24 h after being differentiated with DAPT for 5 days. Scale bars, 360 μm.

4μ8C purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Aug 22:S1074-7613(25)00332-2. [Abstract]

Graphs depicting relative mRNA expression of Muc2 in colon organoids treated with G'9668 or 4μ8C (10 μM) for 24 h after incubation, with or without DAPT for 5 days, measured by RT-qPCR.

4μ8C purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Aug 22:S1074-7613(25)00332-2. [Abstract]

Graphs depicting relative mRNA expression of Agr2 in colon organoids treated with G'9668 or 4μ8C (10 μM) for 24 h after incubation, with or without DAPT for 5 days, measured by RT-qPCR.
Nat Metab

Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice. [Abstract]

2024 Aug;6(8):1601-1615. PMID: 39030389

4μ8C purchased from MedChemExpress. Usage Cited in: Nat Metab. 2024 Aug;6(8):1601-1615. [Abstract]

Xbp1 splicing and Gcg expression in NaHS-treated cells in the presence of 60 μM 4μ8c for 2h (n = 4 for all groups).
Nat Metab

Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis. [Abstract]

2022 Sep;4(9):1166-1184. PMID: 36123394
Nat Cell Biol

SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool. [Abstract]

2023 May;25(5):726-739. PMID: 37142791
Nat Commun

Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling. [Abstract]

2025 Dec 10. PMID: 41372171
Nat Commun

IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis. [Abstract]

2024 May 15;15(1):4114. PMID: 38750057
Exp Hematol Oncol

RNA sequencing identifies novel regulated IRE1-dependent decay targets that affect multiple myeloma survival and proliferation. [Abstract]

2022 Mar 31;11(1):18. PMID: 35361260
J Adv Res

Rutin triggers IRE1-mediated GSDMD-dependent pyroptosis in macrophages to suppress systemic Salmonella infection. [Abstract]

2026 Apr 1:S2090-1232(26)00273-0. PMID: 41932494
Genes Dis

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization. [Abstract]

2022 Dec 29;11(1):464-478. PMID: 37588212
Acta Pharm Sin B

The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1 α/XBP1s pathway. [Abstract]

2022 May;12(5):2315-2329. PMID: 35646520
Cell Death Dis

The OAS1-FASN axis promotes pancreatic cancer by coordinating lipogenic stress and the unfolded protein response. [Abstract]

2026 Jun 3. PMID: 42236684
Cell Death Dis

IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma. [Abstract]

2025 Jul 11;16(1):512. PMID: 40645933
Cell Death Dis

Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma. [Abstract]

2025 Jan 14;16(1):12. PMID: 39805854
Cell Mol Biol Lett

Metabolic disorders sensitise endometrial carcinoma through endoplasmic reticulum stress. [Abstract]

2022 Dec 16;27(1):110. PMID: 36526973
J Exp Med

PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen. [Abstract]

2022 Apr 4;219(4):e20211498. PMID: 35266960
Phytomedicine

Effect of pristimerin on apoptosis through activation of ROS/ endoplasmic reticulum (ER) stress-mediated noxa in colorectal cancer. [Abstract]

2021 Jan;80:153399. PMID: 33202325
J Pharm Anal

2026 May 26.
Cell Death Discov

XBP1 modulates endoplasmic reticulum and mitochondria crosstalk via regulating NLRP3 in renal ischemia/reperfusion injury. [Abstract]

2023 Feb 17;9(1):69. PMID: 36801911
Proc Natl Acad Sci U S A

Necroptosis activates UPR sensors without disrupting their binding with GRP78. [Abstract]

2021 Sep 28;118(39):e2110476118. PMID: 34544877
NPJ Breast Cancer

Endoplasmic reticulum stress inhibits AR expression via the PERK/eIF2α/ATF4 pathway in luminal androgen receptor triple-negative breast cancer and prostate cancer. [Abstract]

2022 Jan 10;8(1):2. PMID: 35013318
Free Radic Biol Med

Cannabigerol induces endoplasmic reticulum stress-mediated apoptosis and ferroptosis via the IRE1α-XBP1 axis in human pancreatic cancer cells. [Abstract]

2026 Mar 21:S0891-5849(26)00242-X. PMID: 41871732
Free Radic Biol Med

TRAF6 mediates vascular remodeling via endoplasmic reticulum stress-mitophagy in hypoxic pulmonary hypertension. [Abstract]

2025 Dec 20:245:237-249. PMID: 41429276
Free Radic Biol Med

TRIB2 promotes pulmonary artery smooth muscle cell proliferation through SERCA2 ubiquitination in pulmonary hypertension. [Abstract]

2025 Nov 8:243:414-433. PMID: 41213438
ACS Appl Mater Interfaces

Polyaniline-Based Glyco-Condensation on Au Nanoparticles Enhances Immunotherapy in Lung Cancer. [Abstract]

2022 Jun 1;14(21):24144-24159. PMID: 35579575
Cell Rep

ALG6 orchestrates coronavirus replication via the endoplasmic reticulum stress-autophagy axis. [Abstract]

2026 Mar 17;45(4):117108. PMID: 41855202
J Pineal Res

Sleep Deprivation Induces Gut Damage via Ferroptosis. [Abstract]

2024 Aug;76(5):e12987. PMID: 38975671
Food Sci Hum Wellness

2026 Mar 3.
Ecotoxicol Environ Saf

Hesperetin protects hippocampal neurons from the neurotoxicity of Aflatoxin B1 in mice. [Abstract]

2024 Jan 1:269:115782. PMID: 38056121
Biochem Pharmacol

Ghrelin attenuates metabolic dysfunction-associated steatotic liver disease by activating glutamine metabolism via inhibition of the IRE1α-XBP-1 pathway. [Abstract]

2025 Jun 26:240:117089. PMID: 40581331
Life Sci

GRP78 blockade overcomes acquired resistance to EGFR-tyrosine kinase inhibitors in non-small cell lung cancer. [Abstract]

2024 Jul 1:348:122681. PMID: 38697281
Acs Biomater Sci Eng

Multifunctional Single-Layered Graphene Quantum Dots Used for Diagnosis of Mitochondrial Malfunction-Related Diseases. [Abstract]

2020 Mar 9;6(3):1727-1734. PMID: 33455364
Front Microbiol

Ire1 inhibitors attenuate Candida albicans pathogenicity and demonstrate potential for application in antifungal therapy. [Abstract]

2025 Sep 3:16:1648467. PMID: 40969430
Mol Neurobiol

CK2α Regulates Endoplasmic Reticulum Stress-Mediated Mitophagy via the PERK/ATF4/CHOP Pathway in Rotenone-Treated SH-SY5Y Cells. [Abstract]

2025 Nov 19;63(1):69. PMID: 41254351
mBio

Quantitative proteomic analysis identifies the unfolded protein response as a host pathway co-opted by ASFV to promote replication. [Abstract]

2025 Dec 5:e0324225. PMID: 41347792
mBio

AUP1 and UBE2G2 complex targets STING signaling and regulates virus-induced innate immunity. [Abstract]

2025 Apr 16:e0060225. PMID: 40237449
J Pathol

Function and mutual interaction of BiP-, PERK-, and IRE1α-dependent signalling pathways in vascular tumours. [Abstract]

2020 Jun;251(2):123-134. PMID: 32166747
Toxicology

Proteasome inhibition induces apoptosis through simultaneous inactivation of MCL-1/BCL-XL by NOXA independent of CHOP and JNK pathways. [Abstract]

2024 Aug 6:153906. PMID: 39117261
Toxicology

Differential susceptibility of BRL cells with/without insulin resistance and the role of endoplasmic reticulum stress signaling pathway in response to acrylamide-exposure toxicity effects in vitro. [Abstract]

2024 May:504:153800. PMID: 38604440
ACS Omega

Combination of Palmitic Acid and Methylseleninic Acid Induces Mitochondria-Dependent Apoptosis via Attenuation of the IRE1α Arm and Enhancement of CHOP in Hepatoma. [Abstract]

2021 Jun 8;6(24):15708-15715. PMID: 34179614
Cell Signal

Unfolded protein response-activated NLRP3 inflammasome contributes to pyroptotic and apoptotic podocyte injury in diabetic kidney disease via the CHOP-TXNIP axis. [Abstract]

2025 Jun:130:111702. PMID: 40020889
Cell Signal

Inhibition of ERO1L induces autophagy and apoptosis via endoplasmic reticulum stress in colorectal cancer. [Abstract]

2024 Dec 8:127:111560. PMID: 39657838
J Dairy Sci

AMPK-endoplasmic reticulum stress axis contributes to lipopolysaccharide-caused mitochondrial dysfunction by regulating mitochondria-associated membrane function in bovine hepatocytes. [Abstract]

2023 Jul;106(7):5146-5164. PMID: 37225589
ACS Infect Dis

Targeting the Inositol-Requiring Enzyme-1 Pathway Efficiently Reverts Zika Virus-Induced Neurogenesis and Spermatogenesis Marker Perturbations. [Abstract]

2020 Jul 10;6(7):1745-1758. PMID: 32329611
Front Cell Neurosci

IRE1α-XBP1 Affects the Mitochondrial Function of Aβ25-35-Treated SH-SY5Y Cells by Regulating Mitochondria-Associated Endoplasmic Reticulum Membranes. [Abstract]

2021 Mar 25;15:614556. PMID: 33841100
FASEB J

SNAI1 is upregulated during muscle regeneration and represses FGF21 and ATF3 expression by directly binding their promoters. [Abstract]

2022 Jul;36(7):e22401. PMID: 35726676
Fish Shellfish Immunol

Grass Carp Reovirus (GCRV) infection activates the PERK-eIF2α pathway to promote the viral replication. [Abstract]

2024 Nov 9:155:110020. PMID: 39528019
J Virol

Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1. [Abstract]

2024 Jun 21:e0081324. PMID: 38904364
Toxins

Activation of the IRE1α Arm, but not the PERK Arm, of the Unfolded Protein Response Contributes to Fumonisin B1-Induced Hepatotoxicity. [Abstract]

2020 Jan 16;12(1):55. PMID: 31963346

4μ8C purchased from MedChemExpress. Usage Cited in: Toxins. 2020 Jan 16;12(1):55. [Abstract]

The effect of the IRE1 specific inhibitor 4μ8C on the expression of apoptosis-related proteins. The cells are exposed to FB1 with or without 4μ8C for 24 h, and the phosphorylation of JNK, Mcl-1, Bak, Bax, and Puma were analyzed by Western blotting. n = 3.
Viruses

Induction of the Unfolded Protein Response during Bovine Alphaherpesvirus 1 Infection. [Abstract]

2020 Sep 2;12(9):974. PMID: 32887282
Cytokine

Triptolide impacts CSF1R expression and reprograms the suppressive function of myeloid-derived suppressor cells via targeting the ER stress pathway. [Abstract]

2026 Jan:197:157068. PMID: 41197245
Infect Immun

Chlamydia psittaci Induces Autophagy in Human Bronchial Epithelial Cells via PERK and IRE1α, but Not ATF6 Pathway. [Abstract]

2022 May 19;90(5):e0007922. PMID: 35435728
Food Chem Toxicol

Mechanisms of aristolochic acid I Hepatotoxicity: Central role of PDK4-Induced mitochondrial dysfunction and hepatic inflammation. [Abstract]

2025 Jun 4:203:115592. PMID: 40480416
Food Chem Toxicol

IRE1 and CaMKKβ pathways to reveal the mechanism involved in microcystin-LR-induced autophagy in mouse ovarian cells. [Abstract]

2021 Jan;147:111911. PMID: 33290805
Fish Physiol Biochem

Regulation of lipid metabolism in grass carp primary hepatocytes by exosomes derived from fatty hepatocytes though GRP78. [Abstract]

2024 Dec;50(6):2287-2299. PMID: 39090453
Mol Biol Cell

Baseline Unfolded Protein Response Signaling Adjusts the Timing of the Mammalian Cell Cycle. [Abstract]

2024 Jun 1;35(6):br12. PMID: 38656789
Theriogenology

Mito-Q promotes porcine oocytes maturation by maintaining mitochondrial thermogenesis via UCP2 downregulation. [Abstract]

2022 May 16;187:205-214. PMID: 35644089
Vet Microbiol

The PERK-eIF2α branch activates the NLRP3 inflammasome through the NF-κB signaling pathway to suppress NDV replication. [Abstract]

2026 May:316:110968. PMID: 41793984
Toxicon

Glycyrol alleviates the combined toxicity of fumonisin B1 and cadmium in vitro and in vivo. [Abstract]

2021 Sep:200:165-172. PMID: 34343521
Vet Microbiol

A rough Brucella mutant induced macrophage death depends on secretion activity of T4SS, but not on cellular Txnip- and Caspase-2-mediated signaling pathway. [Abstract]

2020 May;244:108648. PMID: 32402333
Biochem Biophys Res Commun

Chlamydia trachomatis plasmid-encoded protein pORF5 activates unfolded protein response to induce autophagy via MAPK/ERK signaling pathway. [Abstract]

2020 Jun 30;527(3):805-810. PMID: 32446560
Curr Med Sci

Hypoxia Affects Autophagy in Human Umbilical Vein Endothelial Cells via the IRE1 Unfolded Protein Response. [Abstract]

2023 Aug;43(4):689-695. PMID: 37558862
Mol Cell Toxicol

2025 Jul 18.
Bio Protoc

An Ex Vivo Protocol to Assess IRE1α-Dependent RNA Cleavage Using Total RNA Isolated from Mouse Tissues. [Abstract]

2025 Aug 20;15(16):e5414. PMID: 40901563
bioRxiv

Cell autonomous inflammation in VEXAS is mediated by cGAS-STING. [Abstract]

2026 May 29:2026.05.26.727520. PMID: 42244578
bioRxiv

2026 May 31.
bioRxiv

2026 Feb 24.
bioRxiv

2025 Aug 08.
bioRxiv

2025 February 10.
bioRxiv

2024 September 30.
Research Square Preprint

2024 Mar 15.
Environ Toxicol

Endoplasmic reticulum chaperone GRP78 participates in fluoride-induced autophagy in LS8 cells by regulating the IRE1-TRAF2-JNK pathway. [Abstract]

2023 Jul;38(7):1756-1767. PMID: 37070943

4μ8C purchased from MedChemExpress. Usage Cited in: Environ Toxicol. 2023 Jul;38(7):1756-1767. [Abstract]

4μ8C (20 μM; 1 h) significantly inhibits NaF-induced increased expression of p-IRE1 , GRP78 , p-TRAF2 , p-JNK, and LC3II/I in LS8 cells.
Oxid Med Cell Longev

Stimulation of Sigma-1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment. [Abstract]

2021 Jan 4;2021:8836818. PMID: 33488945

Solvant et solubilité

In Vitro:

DMSO : 33.33 mg/mL (163.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.8976 mL

24.4882 mL

48.9764 mL

5 mM

0.9795 mL

4.8976 mL

9.7953 mL

10 mM

0.4898 mL

2.4488 mL

4.8976 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 15% Cremophor EL 85% Saline

Solubility: 25 mg/mL (122.44 mM); Suspended solution; Need ultrasonic

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

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Références

[1]. Cross BC, et al. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E869-78. [Content Brief]

[2]. Zhang L, et al. IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis. BMC Cell Biol. 2014 Jul 10;15:29. [Content Brief]

[3]. Kemp K, et al. The serine-threonine kinase inositol-requiring enzyme 1α (IRE1α) promotes IL-4 production in T helper cells. J Biol Chem. 2013 Nov 15;288(46):33272-82.

[4]. Tufanli O, et al. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1395-E1404. [Content Brief]

[5]. Nam ST, et al. Suppression of IgE-mediated mast cell activation and mouse anaphylaxis via inhibition of Sykactivation by 8-formyl-7-hydroxy-4-methylcoumarin, 4μ8C. Toxicol Appl Pharmacol. 2017 Oct 1;332:25-31. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.8976 mL	24.4882 mL	48.9764 mL	122.4410 mL
	5 mM	0.9795 mL	4.8976 mL	9.7953 mL	24.4882 mL
	10 mM	0.4898 mL	2.4488 mL	4.8976 mL	12.2441 mL
	15 mM	0.3265 mL	1.6325 mL	3.2651 mL	8.1627 mL
	20 mM	0.2449 mL	1.2244 mL	2.4488 mL	6.1220 mL
	25 mM	0.1959 mL	0.9795 mL	1.9591 mL	4.8976 mL
	30 mM	0.1633 mL	0.8163 mL	1.6325 mL	4.0814 mL
	40 mM	0.1224 mL	0.6122 mL	1.2244 mL	3.0610 mL
	50 mM	0.0980 mL	0.4898 mL	0.9795 mL	2.4488 mL
	60 mM	0.0816 mL	0.4081 mL	0.8163 mL	2.0407 mL
	80 mM	0.0612 mL	0.3061 mL	0.6122 mL	1.5305 mL
	100 mM	0.0490 mL	0.2449 mL	0.4898 mL	1.2244 mL

Keywords

4μ8C

74 Cited Publications

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4μ8C

Kinase Inhibitor Library Mini

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Anti-Aging Compound Library Mini

Cell Cycle/DNA Damage Compound Library

Kinase Inhibitor Library

Anti-Aging Compound Library

Covalent Screening Library

Endoplasmic Reticulum Stress Compound Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

Publications Citing Use of MedChemExpress (MCE) 4μ8C

Activité biologique

Chemical Information

Publications (74)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

4μ8C

Kinase Inhibitor Library Mini

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Anti-Aging Compound Library Mini

Cell Cycle/DNA Damage Compound Library

Kinase Inhibitor Library

Anti-Aging Compound Library

Covalent Screening Library

Endoplasmic Reticulum Stress Compound Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

Publications Citing Use of MedChemExpress (MCE) 4μ8C

Activité biologique

Chemical Information

Publications (74)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

4μ8C Related Classifications

HY-19707 Related Classifications