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Cat. No.: HY-112282

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BI-1408

Name: BI-1408
Brand: MedChemExpress
SKU: HY-112282
Price: 571.00 USD
Availability: InStock
Rating: 5 (1 reviews)

BI-1408 is a potent γ secretase modulator with an IC₅₀ of 0.04 μM for Aβ₄₂.

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CAS No.: 2231075-94-6
Formule: C₂₂H₂₃FN₆
Masse moléculaire:390.46

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BI-1408 Chemical Structure

CAS No.: 2231075-94-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

BI-1408 is a potent γ secretase modulator with an IC₅₀ of 0.04 μM for Aβ₄₂^[1].

IC₅₀ & Target

IC50: 40 nM (Aβ₄₂)^[1]

Chemical Information

CAS No. 2231075-94-6
Masse moléculaire 390.46
Formule C₂₂H₂₃FN₆
SMILES

CC1=CC(F)=CC=C1C2=CC=CN3C2=NC(N[C@@H]4CCC(N(CC)N=C5)=C5C4)=N3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Gerlach K, et al. Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators. Bioorg Med Chem. 2018 Jul 23;26(12):3227-3241. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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