Carnostatine
Based on 2 publication(s) in Google Scholar
Carnostatine (SAN9812) is a potent and selective carnosinase 1 (CN1) inhibitor with a Ki of 11 nM for human recombinant CN1. Carnostatine (SAN9812) can be used for the treatment of diabetic nephropathy (DN).
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- Formule: C10H16N4O4
- Masse moléculaire:256.26
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Publications Citing Use of MedChemExpress (MCE) Carnostatine
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Activité biologique
Description
IC50 & Target
Ki: 11 nM (human CN1)[1]
In Vitro
Carnostatine (SAN9812) also inhibits CN1 activity in human serum and serum of transgenic mice-overexpressing human CN1. Carnostatine, with an IC50 value of 18 nM on human recombinant CN1 at a carnosine concentration of 200 μM, i.e., close to the Km of 190 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Human carnosinase (CNDP1) transgenic mice on a BTBR wt/ob background[1]
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Dosage:3 mg/kg i.v. or 30 mg/kg s.c. (Pharmacokinetic Analysis)
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Administration:Single bolus administration
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Result:Subcutaneous administration of 30 mg/kg led to a sustained reduction in circulating CN1 activity.
Chemical Information
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Masse moléculaire 256.26
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Formule C10H16N4O4
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Synonyms
SAN9812
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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J Neuroinflammation
Acarbose modulates microglial Pkm2 acetylation to reshape immunometabolism and preserve retinal neurons after ischemia-reperfusion. [Abstract]2026 May 2;23(1):206. PMID: 42069589 -
Cell Death Discov
Low-dose TNF-α drives malignant progression and lipid metabolism in glioblastoma through the TRAF2-FASN axis. [Abstract]2026 Apr 9;12(1):242. PMID: 41956989
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carnostatine Related Classifications
HY-112431 Related Classifications
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