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Cat. No.: HY-12648

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FASN-IN-4

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC₅₀ of 10 nM (WO2012064642A1, compound 29). FASN-IN-4 also inhibits SARS-CoV-2 with an EC₅₀ of 18.6 nM.

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Pureté: 99.21%
CAS No.: 1375105-96-6
Formule: C₂₆H₂₇N₃O₄S
Masse moléculaire:477.58

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Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

FASN-IN-4 Chemical Structure

CAS No.: 1375105-96-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (3)
Pureté et documentation
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Activité biologique

Description

FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC₅₀ of 10 nM (WO2012064642A1, compound 29)^[1]. FASN-IN-4 also inhibits SARS-CoV-2 with an EC₅₀ of 18.6 nM^[2].

IC₅₀ & Target

IC50: 10 nM (FASN)^[1]
EC50: 18.6 nM (SARS-CoV-2)^[2]

In Vitro

The FASN inhibitor, FASN-IN-4 inhibits SARS-CoV-2 replication, and has the potential for COVID-19 research^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1375105-96-6
Appearance Solid
Masse moléculaire 477.58
Formule C₂₆H₂₇N₃O₄S
Color White to off-white
SMILES

O=C1COC2(CCN(S(=O)(C3=CC=C(C4=CC=C5C=CC=NC5=C4)C=C3)=O)CC2)CN1C6CC6
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Nat Metab

Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. [Abstract]

2021 Nov;3(11):1466-1475. PMID: 34580494
Sci China Life Sci

NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry. [Abstract]

2022 Feb;65(2):341-361. PMID: 34047913
Cell Biosci

Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma. [Abstract]

2022 Sep 16;12(1):158. PMID: 36114560

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Nicholas D. Adams, et al. Fatty acid synthase inhibitors. WO2012064642A1.

[2]. Junjun Chu, et al. Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat Metab. 2021 Nov;3(11):1466-1475. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

FASN-IN-4

3 Cited Publications

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- In Vitro
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Publications (3)
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FASN-IN-4

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) FASN-IN-4

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FASN-IN-4

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) FASN-IN-4

Activité biologique

Chemical Information

Publications (3)

Pureté et documentation

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FASN-IN-4 Related Classifications

HY-12648 Related Classifications