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Cat. No.: HY-P1485

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Substance P(1-7)

Name: Substance P(1-7)
Brand: MedChemExpress
SKU: HY-P1485
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Substance P(1-7) is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.

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CAS No.: 68060-49-1
Formule: C₄₁H₆₅N₁₃O₁₀
Masse moléculaire:900.04

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Substance P(1-7) Chemical Structure

CAS No.: 68060-49-1

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Activité biologique
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- In Vivo
Chemical Information
Publications (1)
Pureté et documentation
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Activité biologique

Description

Substance P(1-7) is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) gives depressor and bradycardic effects when applied to the nucleus tractus solitarius^[1].

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In Vivo

Substance P (1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P (1-7) is an endogenous modulator of SP actions^[1]. Injection of low doses of Substance P (1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 68060-49-1
Masse moléculaire 900.04
Formule C₄₁H₆₅N₁₃O₁₀
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe
Sequence Shortening

RPKPQQF
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Dermatol Sci

2026 Aug;123(2):63-74. PMID: 42251015

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Herrera-Marschitz M, et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain. Brain Res. 1990 Jun 25;521(1-2):316-20. [Content Brief]

[2]. Sakurada T, et al. Substance P(1-7) antagonizes substance P-induced aversive behaviour in mice. Neurosci Lett. 1988 Dec 19;95(1-3):281-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Substance P(1-7)

1 Cited Publications

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Activité biologique
- Description
- In Vivo
Chemical Information
Publications (1)
Pureté et documentation
Références

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Substance P(1-7)

Publications Citing Use of MedChemExpress (MCE) Substance P(1-7)

Voir tous les produits spécifiques à Isoform Neurokinin Receptor