ACTH (4-9)
ACTH (4-9) is an adrenocorticotropic hormone (ACTH) fragment. ACTH (4-9) is the 4-9 sequence fragment of ACTH.
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- CAS No.: 56236-83-0
- Formule: C42H56N12O9S
- Masse moléculaire:905.03
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Pregnant female mouse or newborn pups[1]
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Dosage:1 mg/kg
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Administration:Subcutaneous injection
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Result:Inhibited learning/memory task performance m males and females mouse.
Chemical Information
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CAS No. 56236-83-0
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Masse moléculaire 905.03
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Formule C42H56N12O9S
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Sequence Shortening
MEHFRW
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Pureté et documentation
Références
[1]. Honour LC, et, al. Pre- and postnatally administered ACTH, Organon 2766 and CRF facilitate or inhibit active avoidance task performance in young adult mice. Peptides. 1988 Jul-Aug;9(4):745-50. [Content Brief]
[2]. Sekita-Krzak J, et, al. Protective effects of ACTH (4-9) in degeneration of hippocampal nerve cells caused by dexamethasone: ultrastructural studies. Ann Univ Mariae Curie Sklodowska Med. 2002;57(2):233-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ACTH (4-9) Related Classifications
HY-P3978 Related Classifications
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