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Cat. No.: HY-W1142089

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ActRIIB-IN-2

ActRIIB-IN-2 is an ActRIIB inhibitor with an IC₅₀ of 1.1 nM. ActRIIB-IN-2 can be used for the research of cancer cachexia.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 3039974-32-5
Formule: C₂₆H₂₅N₅
Masse moléculaire:407.51

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ActRIIB-IN-2 Chemical Structure

CAS No.: 3039974-32-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

ActRIIB-IN-2 is an ActRIIB inhibitor with an IC₅₀ of 1.1 nM. ActRIIB-IN-2 can be used for the research of cancer cachexia^[1].

IC₅₀ & Target

^[1]

ACVR2B

1.1 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform TGF-β Receptor :

In Vitro

ActRIIB-IN-2 (2.5 μM; 48 h) achieved a 90.87% reversal rate in myotube atrophy^[1].
ActRIIB-IN-2 (Compound 3) potently inhibits ActRIIB in a cell-free biochemical assay with an IC₅₀ of 1.1 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ActRIIB-IN-2 (10 mg/kg; daily for 16 days) alleviates weight loss, muscle atrophy, and muscle strength in BABL/c mice inoculated with CT26 cells without affecting tumor size, and slightly improves appetite^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice (inoculated with 1 million C26 cells in each axilla to establish a colon cancer model)^[1]
Dosage:

10 mg/kg
Administration:

i.p.; daily for 16 days
Result:

Alleviated weight loss to some extent.
Reduced tumor volume, but not significantly.
Improved appetite.
Significantly enhanced muscle grip strength.
Improved skeletal muscle atrophy to some extent.
Significantly alleviated the reduction in the cross-sectional area of the gastrocnemius muscle.

Chemical Information

CAS No. 3039974-32-5
Masse moléculaire 407.51
Formule C₂₆H₂₅N₅
SMILES

CN(CC1)CCN1C(C=C2)=CC=C2C3=CC4=C(NC=C4C5=CC6=C(NC=C6)C=C5)N=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Dong XC, et al. 7-azaindole compounds, preparation method therefor, and use thereof. China, WO2024114661 A. 2024-06-06.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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