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Cat. No.: HY-N21682

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Adhumulone

Adhumulone is an α-acid derived from hops and a selective AKR1B10 inhibitor, with IC₅₀ values of 5.41-29.27 μM and K_i values of 3.27-16.79 μM against human AKR1B10. Adhumulone inhibits AKR1B10-mediated reduction of Farnesol (HY-Y0248A) as a competitive inhibitor, and it also suppresses the reduction of DL-Glyceraldehyde (HY-128748) and Farnesal substrates. Adhumulone is useful for research on ras-dependent malignancies.

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CAS No.: 31769-65-0
Formule: C₂₁H₃₀O₅
Masse moléculaire:362.46

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Adhumulone Chemical Structure

CAS No.: 31769-65-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]^[2]

AKR1B10

5.41-29.27 μM (IC₅₀)

AKR1B10

3.27-16.79 μM (Ki)

In Vitro

Adhumulone (Compound 1) selectively inhibits recombinant human AKR1B10 when DL-Glyceraldehyde (HY-128748) is used as the substrate, with an IC₅₀ of 5.41 µM and a K_i value of 3.27 μM, while its activity against AKR1A1 and AKR1B1 is much weaker^[1].
Adhumulone acts as a competitive inhibitor of recombinant human AKR1B10-mediated reduction of Farnesol (HY-Y0248A), with an IC₅₀ of 29.27 µM and a K_i of 16.79 µM^[1].
Adhumulone (41c) is a major α-acid sensory metabolite in fresh Humulus lupulus L. hop pellets, with concentrations ranging from 5-15% across 75 commercial hop varieties^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 31769-65-0
Masse moléculaire 362.46
Formule C₂₁H₃₀O₅
SMILES

O=C(C(CC)C)C(C(O)=C1C/C=C(C)\C)=C(O)C(O)(C/C=C(C)\C)C1=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Seliger JM, et al. Selective Inhibition of Human AKR1B10 by n-Humulone, Adhumulone and Cohumulone Isolated from Humulus lupulus Extract. Molecules. 2018 Nov 21;23(11):3041.

[2]. Dresel M, et al. The Bitter Chemodiversity of Hops (Humulus lupulus L.). Journal of agricultural and food chemistry. 2016;64(41):7789-7799. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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