Anti-aging agent 2
Anti-aging agent 2 is an anti-aging agent. Anti-aging agent 2 attenuates senescence-associated secretory phenotype (SASP), alleviates cell cycle arrest, reduces the levels of senescence markers in renal tissues, and downregulates the expression of p21, p16 and p53 in the kidney. Anti-aging agent 2 improves renal function and alleviates renal fibrosis. Anti-aging agent 2 extends the lifespan of Caenorhabditis elegans. Anti-aging agent 2 can be used in the research of chronic kidney disease.
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- Formule: C26H24FNO3
- Masse moléculaire:417.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NRK-52E | IC50 |
>100 μM
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Cytotoxicity against rat renal NRK-52E cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay.
Cytotoxicity against rat renal NRK-52E cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay.
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42501452 |
| MRC5 | IC50 |
>100 μM
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Cytotoxicity against human embryonic lung fibroblast MRC-5 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay.
Cytotoxicity against human embryonic lung fibroblast MRC-5 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay.
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42501452 |
In Vitro
Anti-aging agent 2 (Compound C36) (5-100 μM; 72 h) has low cytotoxicity in NRK-52E and MRC-5 cells, with an IC50 > 100 μM after 72 h[1].
Anti-aging agent 2 (10 μM; 72 h) reduces senescence markers p21 and SA-β-gal and restores AMPK-mTOR pathway homeostasis in Mitomycin C (HY-13316)-induced senescent NRK-52E cells[1].
Anti-aging agent 2 (10 μM; 72 h) reduces senescence markers p21, p16, and γ-H2AX in replicative senescent MRC-5 cells (passage 31)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NRK-52E rat renal cells, MRC-5 human embryonic lung fibroblasts
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Concentration:5-100 μM
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Incubation Time:72 h
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Result:Exhibited low cytotoxicity, with an IC50 > 100 μM in both NRK-52E and MRC-5 cells.
Maintained cell viability near 100% of control across all tested concentrations.
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Cell Line:Mitomycin C-induced senescent NRK-52E rat renal cells
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Concentration:10 μM
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Incubation Time:72 h
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Result:Significantly downregulated the expression of senescence-associated markers p21 and SA-β-gal.
Restored mTOR protein levels and reduced the p-AMPK/AMPK ratio, reestablishing metabolic homeostasis in the AMPK-mTOR pathway.
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Cell Line:Replicative senescent MRC-5 human embryonic lung fibroblasts (passage 31)
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Concentration:10 μM
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Incubation Time:72 h
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Result:Significantly decreased the expression of senescence-associated markers p21, p16, and γ-H2AX.
In Vivo
Anti-aging agent 2 (5-20 mg/kg) improves liver and kidney function, reduces SASP levels, and downregulates renal senescence markers in Doxorubicin (HY-15142A)-induced senescent mice, with the 20 mg/kg dose delivering the most prominent effect[1].
Anti-aging agent 2 (5-20 mg/kg) improves renal function, reduces SASP levels, alleviates renal fibrosis, and downregulates renal senescence markers in mice with UIRI-induced chronic kidney disease[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Caenorhabditis elegans[1]
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Dosage:64 mg/L
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Administration:continuous exposure in culture medium
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Result:Extended mean lifespan by 11.49% compared to control.
Significantly increased body-bending frequency on day 8 compared to control and lead compound C1.
Elevated pharyngeal pumping rates on days 8 and 11 compared to control and lead compound C1.
Improved egg-laying behavior on days 2, 3, and 4 relative to control and lead compound C1.
Chemical Information
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Masse moléculaire 417.47
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Formule C26H24FNO3
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SMILES
COC1=CC=C(C2=NC3=CC(OC(C)C)=C(F)C=C3C(OCC4=CC=CC=C4)=C2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-aging agent 2 Related Classifications
HY-187429 Related Classifications
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