Anti-inflammatory agent 74
Anti-inflammatory agent 74 (B5) is an anti-inflammatory agent that can inhibit NO, IL-6, and TNF-α, with IC50 values of 10.88 μM and 4.93 μM for NO and IL-6, respectively. Anti-inflammatory agent 74 alleviates acute lung injury (ALI) by regulating inflammatory mediators and inhibiting the MAPK and NF-κB signaling pathways.
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- Formule: C41H51NO14
- Masse moléculaire:781.84
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
IC50 & Target
IC50: 10.88 μM (NO)[1].
IC50: 4.92 μM (IL-6)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
>25 μM
Compound: B5
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Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced TNF-alpha production preincubated with compound for 1 hr followed by LPS-induction and measured after 24 hrs by ELISA analysis relative to control
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced TNF-alpha production preincubated with compound for 1 hr followed by LPS-induction and measured after 24 hrs by ELISA analysis relative to control
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[PMID: 38342013] |
| RAW264.7 | IC50 |
10.88 μM
Compound: B5
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Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO release preincubated with compound for 1 hr followed by LPS-induction and measured after 24 hrs by ELISA analysis relative to control
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced NO release preincubated with compound for 1 hr followed by LPS-induction and measured after 24 hrs by ELISA analysis relative to control
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[PMID: 38342013] |
| RAW264.7 | IC50 |
4.93 μM
Compound: B5
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Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced IL-6 production preincubated with compound for 1 hr followed by LPS-induction and measured after 24 hrs by ELISA analysis relative to control
Antiinflammatory activity in mouse RAW264.7 cells assessed as reduction in LPS-induced IL-6 production preincubated with compound for 1 hr followed by LPS-induction and measured after 24 hrs by ELISA analysis relative to control
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[PMID: 38342013] |
Chemical Information
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Masse moléculaire 781.84
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Formule C41H51NO14
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SMILES
[H][C@]12CO[C@H]([C@]1(CO[C@@H]2C3=CC=C(C(OC)=C3)O[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)COC([C@@H](NC(OC(C)(C)C)=O)CC5=CC=CC=C5)=O)[H])C6=CC=C(C(OC)=C6)OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 74 Related Classifications
HY-157809 Related Classifications
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