Antibacterial agent 343
Antibacterial agent 343 (Compound 47) is an Antibacterial agent. Antibacterial agent 343 binds to the allosteric site of PBP2a to open its active site. Antibacterial agent 343 disrupts bacterial cell membranes, leading to protein leakage. Antibacterial agent 343 interacts with DNA and inhibits replication and transcription. Antibacterial agent 343 induces ROS accumulation. Antibacterial agent 343 exhibits antibacterial activity against MRSA, Staphylococcus aureus, and Enterococcus faecalis. Antibacterial agent 343 can be used for the research of methicillin-resistant Staphylococcus aureus infections.
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- Formule: C33H34N8O9S2
- Masse moléculaire:750.80
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Antibacterial agent 343 exhibits antibacterial activity and potently inhibits MRSA, with an MIC50 of 0.5 μg/mL[1].
Antibacterial agent 343 (5-40 μg/mL; 24 h) exhibits low cytotoxicity against normal LO2 and BEAS-2B cells, with no significant reduction in cell viability observed even at concentrations up to 40 μg/mL after 24 h of treatment[1].
Antibacterial agent 343 (0.25-1 μg/mL; 0-14 h) inhibits the growth of MRSA in a concentration-dependent manner[1].
Antibacterial agent 343 (0.5-4 μg/mL) promotes concentration-dependent reactive oxygen species (ROS) accumulation in MRSA, and the ROS level increases to 2.5 times that of the control group at 1× MIC, thereby inducing oxidative stress[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LO2 normal human liver cells, BEAS-2B normal human bronchial epithelial cells
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Concentration:5-40 μg/mL
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Incubation Time:24 h
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Result:Did not cause any significant reduction in cell viability in either LO2 or BEAS-2B cell lines at all tested concentrations.
Chemical Information
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Masse moléculaire 750.80
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Formule C33H34N8O9S2
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SMILES
NC1=NC(/C(C(NC2C(N3C2SCC(CN4CCN(C5=CC=C6C7=C5C=CC=C7C(N(C(CO)CO)C6=O)=O)CC4)=C3C(O)=O)=O)=O)=N/OC)=CS1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 343 Related Classifications
HY-183291 Related Classifications
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- Antibacterial agent 343
- Antibacterial agent343
- Antibacterial agent-343
- Bacterial
- DNA/RNA Synthesis
- DNA Alkylator/Crosslinker
- Reactive Oxygen Species (ROS)
- Penicillin-binding protein (PBP)
- MRSA
- human RBC
- reactive oxygen species
- bacterial cell membranes
- methicillin-resistant staphylococcus aureus infection
- PBP2a
- BEAS-2B
- calf thymus DNA
- biofilm
- LO2
- Inhibitor
- inhibitor
- inhibit