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Cat. No.: HY-139828

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Anticancer agent 14

Anticancer agent 14 is a lead compound (IC₅₀: 0.20 to 0.65 μM) that induces apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells.

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CAS No.: 2762698-14-4
Formule: C₂₉H₃₄N₂O₃
Masse moléculaire:458.59

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Anticancer agent 14 Chemical Structure

CAS No.: 2762698-14-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Anticancer agent 14 is a lead compound (IC₅₀: 0.20 to 0.65 μM) that induces apoptosis, cell cycle arrest, and loss of mitochondrial membrane potential in breast cancer cells.

Cellular Effect

Cell Line	Type	Value	Description	References
LA7	IC₅₀	0.19 μM Compound: 13d; 13d-f	Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34726897]
LA7	IC₅₀	0.24 μM Compound: 13d; 13d-f	Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 34726897]
LA7	IC₅₀	0.66 μM Compound: 13d; 13d-f	Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against rat LA7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 34726897]
MCF-10A	IC₅₀	>18 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34726897]
MCF-10A	IC₅₀	>25 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 34726897]
MCF7	IC₅₀	0.2 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 34726897]
MCF7	IC₅₀	0.25 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34726897]
MCF7	IC₅₀	0.3 μM Compound: 13d; 13d-f	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 34726897]
MDA-MB-231	IC₅₀	0.65 μM Compound: 13d; 13d-f	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay	[PMID: 34726897]
MDA-MB-231	IC₅₀	0.7 μM Compound: 13d; 13d-f	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 34726897]
MDA-MB-231	IC₅₀	0.7 μM Compound: 13d; 13d-f	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 34726897]

Chemical Information

CAS No. 2762698-14-4
Masse moléculaire 458.59
Formule C₂₉H₃₄N₂O₃
SMILES

COC(C=C1)=CC=C1C[C@H]2COC3=CC=CC=C3N2CC4=CC=C(OCCN5CCCC5)C=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jana AK, et al. Tyrosine-Derived Novel Benzoxazine Active in a Rat Syngenic Mammary Tumor Model of Breast Cancer. J Med Chem. 2021 Nov 11;64(21):16293-16316. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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