Anticancer agent 57
Anticancer agent 57 (compound 14) potently inhibits MDA-MB-231, MDA-MB-468, and MCF-7 cell lines, with IC50s of 6.43 ~ 8.00 μM. Anticancer agent 57 induces cell cycle arrest and significantly promotes apoptosis. Anticancer agent 57 inhibits tumor growth in nude mice xenografted with MADMB-231 cells. Anticancer agent 57 can be used for researching triple negative breast cancer (TNBC).
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- CAS No.: 2408017-71-8
- Formule: C20H21Cl2NO2
- Masse moléculaire:378.29
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
IC50 & Target
IC50: 8.00 ± 0.07 μM in MDA-MB-231, 7.30 ± 0.04 μM in MDA-MB-468, 6.43 ± 0.18 μM in MCF-7[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
2.44 μM
Compound: 14
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Antimigratory activity in human MCF7 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
Antimigratory activity in human MCF7 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
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[PMID: 31838326] |
| MCF7 | IC50 |
6.43 μM
Compound: 14
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
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[PMID: 31838326] |
| MDA-MB-231 | IC50 |
3 μM
Compound: 14
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Antimigratory activity in human MDA-MB-231 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
Antimigratory activity in human MDA-MB-231 cells assessed as inhibition of cell motility after 24 hrs by microscopic analysis
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[PMID: 31838326] |
| MDA-MB-231 | IC50 |
3.94 mM
Compound: Fig 1C, Cpd 2
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Antiproliferative activity against human MDA-MB-231 cells
Antiproliferative activity against human MDA-MB-231 cells
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[PMID: 38750906] |
| MDA-MB-231 | IC50 |
8 μM
Compound: 14
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
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[PMID: 31838326] |
| MDA-MB-468 | IC50 |
7.3 μM
Compound: 14
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Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by microplate reader analysis
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[PMID: 31838326] |
Chemical Information
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CAS No. 2408017-71-8
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Masse moléculaire 378.29
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Formule C20H21Cl2NO2
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SMILES
O=C(C1=CC=CC(OC)=C1)/C=C/C2=CC=C(N(CCCl)CCCl)C=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 57 Related Classifications
HY-146452 Related Classifications
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