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Cat. No.: HY-146169

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Antitumor agent-68

Antitumor agent-68 is a potent tubulin inhibitor. Antitumor agent-68 shows potent anticancer activity with IC₅₀s of 3.6 and 3.8 μM for HeLa and MCF-7 cells, respectively. Antitumor agent-68 exhibits good scavenging activity of ROS and DPPH radical in a dose-dependent manner. Antitumor agent-68 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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CAS No.: 2566497-96-7
Formule: C₁₇H₁₁NO₂
Masse moléculaire:261.27

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Antitumor agent-68 Chemical Structure

CAS No.: 2566497-96-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Antitumor agent-68 is a potent tubulin inhibitor. Antitumor agent-68 shows potent anticancer activity with IC₅₀s of 3.6 and 3.8 μM for HeLa and MCF-7 cells, respectively. Antitumor agent-68 exhibits good scavenging activity of ROS and DPPH radical in a dose-dependent manner^[1]. Antitumor agent-68 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

IC50: 3.6 μM (HeLa), 3.8 µM (MCF-7)^[1]

In Vitro

Antitumor agent-68 (Compound 7) exhibits anticancer activity with IC₅₀s of 3.6 and 3.8 μM, for HeLa and MCF-7 cells, respectively^[1].
Antitumor agent-68 (10 μΜ; 24 hours) causes a 3-fold reduction of ROS production induced by Men in 3T3-L1 cells, and an EC₅₀ of DPPH radical scavenging is 8.30 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HeLa, MCF-7, 3T3-L1
Concentration:

10 μM
Incubation Time:

24 hours
Result:

Showed anticancer activity by blocking the tubulin polymerization reaction.
Reduced production of ROS, and scavenged DPPH radical.

Related Protocols :

Chemical Information

CAS No. 2566497-96-7
Masse moléculaire 261.27
Formule C₁₇H₁₁NO₂
SMILES

O=C(OC1=CC2=C(NC=C2)C=C1)C#CC3=CC=CC=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Domenico Iacopetta, et al. Synthesis, anticancer and antioxidant properties of new indole and pyranoindole derivatives. Bioorg Chem. 2020 Dec;105:104440. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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