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Cat. No.: HY-125612

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Artonin E

(Synonyms: 5'-Hydroxymorusin)

Artonin E (5'-Hydroxymorusin) is a known prenylated flavonoid that induces apoptosis and arrests the cell cycle in S phase. Artonin E can induce anti-proliferative effects through mitochondrial pathway dysregulation and can be used in cancer research.

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CAS No.: 129683-93-8
Formule: C₂₅H₂₄O₇
Masse moléculaire:436.45

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Artonin E Chemical Structure

CAS No.: 129683-93-8

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
1A9	ED₅₀	<1.25 μg/mL Compound: 12	Cytotoxicity against human 1A9 cells Cytotoxicity against human 1A9 cells	[PMID: 15165133]
A549	ED₅₀	8.5 μg/mL Compound: 12	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 15165133]
CAKI-1	ED₅₀	9.7 μg/mL Compound: 12	Cytotoxicity against human Caki1 cells Cytotoxicity against human Caki1 cells	[PMID: 15165133]
HCT-8	ED₅₀	3.3 μg/mL Compound: 12	Cytotoxicity against human HCT8 cells Cytotoxicity against human HCT8 cells	[PMID: 15165133]
KB	ED₅₀	6.5 μg/mL Compound: 12	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 15165133]
MCF7	ED₅₀	2.2 μg/mL Compound: 12	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 15165133]
MDA-MB-231	ED₅₀	3 μg/mL Compound: 12	Cytotoxicity against human MDA-MB-231 cells Cytotoxicity against human MDA-MB-231 cells	[PMID: 15165133]
P388	IC₅₀	0.14 μM Compound: 9	Antiproliferative activity against mouse P388 cells assessed as reduction in cell viability Antiproliferative activity against mouse P388 cells assessed as reduction in cell viability	[PMID: 30830783]
PC-3	ED₅₀	6.9 μg/mL Compound: 12	Cytotoxicity against human PC3 cells Cytotoxicity against human PC3 cells	[PMID: 15165133]
SK-MEL-2	ED₅₀	4.3 μg/mL Compound: 12	Cytotoxicity against human SK-MEL-2 cells Cytotoxicity against human SK-MEL-2 cells	[PMID: 15165133]
U-87MG ATCC	ED₅₀	6.4 μg/mL Compound: 12	Cytotoxicity against human U87MG cells Cytotoxicity against human U87MG cells	[PMID: 15165133]

In Vitro

Artonin E (0-100 μg/mL, 24-72 h) acts on SKOV-3 cells, T1074 cells, human periodontal ligament fibroblasts and CHO cells with the IC₅₀ values of 12.83, 44.8, 67 and 57.6 μg/mL, respectively . And it can reduce the cell viability of SKOV-3 cells in a time-dependent manner^[1].
Artonin E(0-20 μg/mL, 24 h) can inhibit the colony formation of SKOV-3 cells in a dose-dependent manner. At 5 μg/mL, almost half of the colonies were reduced. When using 15 and 20 μg/mL, No colonies formed^[1].
Artonin E (8 μg/mL, 24-72 h) can induce the depletion of SKOV-3 cells in S phase, and at 72 h, the accumulation of cells arrested in S phase was significantly increased, while the ratio of cells in G0/G1 phase decreased^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

SKOV-3 cell lines
Concentration:

8 μg/mL
Incubation Time:

24, 48, 72 h
Result:

Induced ROS formation.
Induced disruption of mitochondrial membrane potential and release of cytochrome c.
Significantly upregulated the protein expression levels of caspase-9 and -3,up-regulated Bax and inhibited the expression of Bcl-2, HSP70 and survivin.

Chemical Information

CAS No. 129683-93-8
Masse moléculaire 436.45
Formule C₂₅H₂₄O₇
SMILES

O=C1C2=C(O)C=C3C(C=CC(C)(C)O3)=C2OC(C4=CC(O)=C(O)C=C4O)=C1C/C=C(C)\C
Synonyms

5'-Hydroxymorusin
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Mashitoh Abd Rahman, et al. Artonin E Induces Apoptosis via Mitochondrial Dysregulation in SKOV-3 Ovarian Cancer Cells. PLoS One. 2016 Mar 28;11(3):e0151466. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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