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Cat. No.: HY-P1699

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Aurantimycin A

Aurantimycin A is a pore-forming antibacterial agent. Aurantimycin A has activity against Gram-positive bacteria, including Bacillus subtilis and Listeria monocytogenes, but has no activity against Gram-negative bacteria or fungi. Aurantimycin A can be used in research related to bacterial infections.

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CAS No.: 162478-50-4
Formule: C₃₈H₆₄N₈O₁₄
Masse moléculaire:856.96

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Aurantimycin A Chemical Structure

CAS No.: 162478-50-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

In Vitro

Bacterial InfectionFungal InfectionOthers

Bacterial Infection

Aurantimycin A shows an MIC of 1.28 µg/mL in B. subtilis BSAH1 after xylose-induced expression of lieAB^[4].

Bacterial Infection

Fungal Infection

Aurantimycin A (compound 1) (0.007-0.08 μg/mL; 18 h (bacteria); 42 h (fungi)) inhibits Gram-positive bacteria with MICs ranging from 0.007 to 0.08 μg/mL, and is inactive against Gram-negative bacteria and fungi at MIC >>100 μg/mL^[5].

Others

Aurantimycin A (compound 1) increases the conductivity of soybean phosphatidylcholine black lipid membranes in a concentration-dependent manner and forms membrane pores at concentrations above 0.1 µM^[1].
Aurantimycin A (compound AA) (4 h) antagonizes 5-HT- and histamine-induced contraction of guinea pig tracheal rings, with IC₅₀ values of 0.50 μM and 1.96 μM, respectively^[3].
Aurantimycin A (48-72 h) is cytotoxic to L-929 mouse fibroblasts, with an IC₅₀ of 7 ng/mL^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 162478-50-4
Masse moléculaire 856.96
Formule C₃₈H₆₄N₈O₁₄
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (281 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Grigoriev P, et al. Formation of membrane pores by aurantimycins A and B, new lipopeptide antibiotics from Streptomyces aurantiacus. Bioelectrochemistry and Bioenergetics. 1995;36:57-59.

[2]. Engelgeh T, et al. ClpP2 proteasomes and SpxA1 determine Listeria monocytogenes tartrolon B hyper-resistance. PLoS genetics. 2025 Apr;21(4):e1011621.

[3]. Assem EK, et al. Pharmacological actions of a new synthetic cyclodepsipeptide, the A83586C-citropeptin hybrid, on complement C5a and G-Proteins. Inflammation Research. 2008 Apr 1;57:21.

[4]. Hauf S, et al. Elements in the LftR Repressor Operator Interface Contributing to Regulation of Aurantimycin Resistance in Listeria monocytogenes. Journal of bacteriology. 2021 Apr 21;203(10):e00503-20.

[5]. Gräfe U, et al. Aurantimycins, New Depsipeptide Antibiotics from Streptomyces Aumntiacus IMET 43917 Production, Isolation, Structure Elucidation, and Biological Activity. The Journal of antibiotics. 1995 Feb 25;48(2):119-25. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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