AVI-4206
AVI-4206 is a selective Mac1 inhibitor with an lC50 of 64 nM. AVI-4206 reduces viral replication, restores an interferon response, and leads to a survival benefit in an animal model of SARS-CoV-2 infection. AVI-4206 can be used the study of SARS-CoV-2 infection.
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- CAS No.: 3105041-48-0
- Formule: C19H23N7O2
- Masse moléculaire:381.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
AVI-4206 (0.1-1000000 nM) inhibits the catalytic activity of Mac1 with an IC50 of 64 nM in the auto
ADP-ribosylated PARP10 and a coupled NudT5/AMP-Glo assay[1].
AVI-4206 (10 μM) engages Mac1 with high potency and selectivity in A549 cells[1].
AVI-4206 (0.01-10000 nM) shows limited efficacy against SARS-CoV-2 infection in Vero-TMPRSS2 or A549-ACE2h cells[1].
AVI-4206 (0.16-100 μM, 24-72 h) reduces viral particle production after Mac1 deficient virus (WA1 N40D mutant) infection[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female K18-hACE2 mice were infected with WA1 N40D mutant, which lacks Mac1 catalytic activity[1]
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Dosage:100 mg/kg
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Administration:i.p., twice daily for 7 days (until 5 days post-infection)
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Result:Showed weight loss at 4 days post-infection, but the extent of weight loss was about 5-10% lower on average at days 5-7 post-infection compared with respective vehicle-treated groups.
Reduced disease severity and prevent death in the K18-hACE2 model.
Showed the faster clearance of viral load in the lungs.
Increased the levels of antiviral cytokines IP-10, IL-2, IL-6, and TNF-α in lung tissue.
Chemical Information
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CAS No. 3105041-48-0
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Masse moléculaire 381.43
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Formule C19H23N7O2
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SMILES
O=C(NCC)NC1=CC=CC2=C1NC3=NC=NC(NN4C(C)(C)CCC4=O)=C32
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AVI-4206 Related Classifications
HY-175461 Related Classifications
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