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Cat. No.: HY-133906

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AX13057

AX13057 is a KIAA1363 inhibitor with an IC₅₀ of 130 nM. AX13057 exhibits tumor penetration and is orally active. AX13057 can be used for research on ovarian cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1397274-79-1
Formule: C₁₆H₁₈BrNO₂
Masse moléculaire:336.23

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AX13057 Chemical Structure

CAS No.: 1397274-79-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

AX13057 is a KIAA1363 inhibitor with an IC₅₀ of 130 nM. AX13057 exhibits tumor penetration and is orally active. AX13057 can be used for research on ovarian cancer^[1].

IC₅₀ & Target

^[1]

KIAA1363

130 nM (IC₅₀)

In Vivo

Anti-cancer

AX13057 (100 mg/kg; p.o. and i.p.) inhibits intratumoral KIAA1363 in SK-OV-3 xenograft-bearing female SCID mice, producing greater inhibition after i.p. dosing than after p.o. dosing^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SCID (female)^[1]
Dosage:

100 mg/kg (p.o.); 100 mg/kg (i.p.)
Administration:

p.o.; i.p.
Result:

Inhibited tumor KIAA1363 by 22% after p.o. dosing with AX13057 at 100 mg/kg.
Inhibited intratumoral human KIAA1363 by 64% and mouse heart KIAA1363 by 66% after i.p. dosing with AX13057 at 100 mg/kg.

Chemical Information

CAS No. 1397274-79-1
Masse moléculaire 336.23
Formule C₁₆H₁₈BrNO₂
SMILES

O=C(OC=1C=CC2=CC(=CC=C2C1Br)CCC)N(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Shreder KR, et al. Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1). Bioorganic & medicinal chemistry letters. 2012 Sep 01;22(17):5748-51. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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