Bis-T-23
Based on 1 Customer Validation
Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 96.07%
- CAS No.: 171674-76-3
- Formule: C23H20N4O8
- Masse moléculaire:480.43
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorate proteinuria by altering actin dynamics[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorates or prevented proteinuria and diminished mesangial matrix expansion in diverse genetic and chronic models of glomerular disease in rodents[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats (8 weeks old, males); Mice[1]
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Dosage:20, 40 mg/kg; 40 mg/kg
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Administration:Intraperitoneal injection; signle, once for 6 consecutive days
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Result:Specifically reduced proteinuria on days 18 and 24.
Caused a transient reduction of proteinuria (single dose) in PKCε KO mice.
Completely prevented the onset of high-level proteinuria in the CD2AP KO mice.
Significantly extended the lifespans of CD2AP KO mice.
Led to improved glomerular histology with less mesangial matrix accumulation.
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Animal Model:Zebrafish[1]
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Dosage:1 ng
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Administration:Injection
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Result:Promoted oligomerization of zebrafish Dyn2.
Increased the number of focal adhesions (FAs) and stress fibers in cultured podocytes.
Chemical Information
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CAS No. 171674-76-3
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Appearance Solid
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Masse moléculaire 480.43
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Formule C23H20N4O8
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Color Light yellow to yellow
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SMILES
O=C(/C(C#N)=C/C1=CC(O)=C(C(O)=C1)O)NCCCNC(/C(C#N)=C/C2=CC(O)=C(C(O)=C2)O)=O
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Synonyms
AG1717
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (208.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.0815 mL | 10.4073 mL | 20.8147 mL | 52.0367 mL |
| 5 mM | 0.4163 mL | 2.0815 mL | 4.1629 mL | 10.4073 mL | |
| 10 mM | 0.2081 mL | 1.0407 mL | 2.0815 mL | 5.2037 mL | |
| 15 mM | 0.1388 mL | 0.6938 mL | 1.3876 mL | 3.4691 mL | |
| 20 mM | 0.1041 mL | 0.5204 mL | 1.0407 mL | 2.6018 mL | |
| 25 mM | 0.0833 mL | 0.4163 mL | 0.8326 mL | 2.0815 mL | |
| 30 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7346 mL | |
| 40 mM | 0.0520 mL | 0.2602 mL | 0.5204 mL | 1.3009 mL | |
| 50 mM | 0.0416 mL | 0.2081 mL | 0.4163 mL | 1.0407 mL | |
| 60 mM | 0.0347 mL | 0.1735 mL | 0.3469 mL | 0.8673 mL | |
| 80 mM | 0.0260 mL | 0.1301 mL | 0.2602 mL | 0.6505 mL | |
| 100 mM | 0.0208 mL | 0.1041 mL | 0.2081 mL | 0.5204 mL |
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