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BKCa activator-1

BKCa activator-1 (Compound 51b) is the orally active activator for the calcium-activated potassium channel BKCa with an EC50 of 2.82 μM. BKCa activator-1 increases K+ efflux, leads to cell membrane hyperpolarization, thereby inhibiting smooth muscle contraction. BKCa activator-1 alleviates urinary incontinence in spontaneously hypertensive rat (SHR) model, exhibits antitussive effect in puinea pig cough model.

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  • Formule: C22H23F7N2O3
  • Masse moléculaire:496.42
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • BKCa activator-1 Chemical Structure
    BKCa activator-1 Chemical Structure
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  • BKCa activator-1 Chemical Structure
    BKCa activator-1 Chemical Structure
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  • BKCa activator-1